128550-06-1 Usage
Description
(N^1,N^4,N^9,N^13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is a complex organic compound characterized by its multiple tert-butoxycarbonyl groups and amino groups. (N1,N4,N9,N13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is known for its utility in organic synthesis and pharmaceutical applications due to its unique structural features.
Uses
Used in Organic Synthesis:
(N^1,N^4,N^9,N^13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is used as a protecting group in organic synthesis. The reason for this application is that the tert-butoxycarbonyl groups can be selectively removed under mild conditions, revealing the amino groups and allowing for further reactions.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (N^1,N^4,N^9,N^13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is used as a building block for the development of new drugs. The presence of multiple amino groups and the triazahexadecane backbone provides flexibility and rigidity, which can be exploited in the design of novel drug candidates.
Used in Peptide Bond Formation:
(N^1,N^4,N^9,N^13-tetra-tert-butoxycarbonyl)-1,16-diamino-4,9,13-triazahexadecane is also used in the formation of peptide bonds. The multiple amino groups in the compound facilitate the creation of these bonds, which are crucial for the structure and function of proteins and peptides.
Check Digit Verification of cas no
The CAS Registry Mumber 128550-06-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,5,5 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128550-06:
(8*1)+(7*2)+(6*8)+(5*5)+(4*5)+(3*0)+(2*0)+(1*6)=121
121 % 10 = 1
So 128550-06-1 is a valid CAS Registry Number.
128550-06-1Relevant articles and documents
Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes
Geall, Andrew J.,Blagbrough, Ian S.
, p. 443 - 446 (1998)
Polyamine amides are useful in gene delivery as synthetic (non-viral) vectors or mimics of polycationic histones. The application of a homologation strategy, based upon reductive alkylation, allows unsymmetrical polyamine amides to be prepared in good yie
NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS
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Page/Page column 51, (2010/04/03)
The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C1-4alkyI, - A represents CO(CH2)n or CONH(CH2)n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.
Polyamines and their use as antibacterial and sensitizing agents
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Page/Page column 10, (2010/11/28)
Polyamines with varying chain-lengths were evaluated for antimicrobial activity in order to test the hypothesis that these bis-cationic amphipathic compounds may also bind to and permeabilize intact Gram negative bacterial membranes. The compounds were found to possess significant antimicrobial activity and mediated via permeabilization of bacterial membranes. Homologated spermine, bis-acylated with C8 or C9 chains was found to profoundly sensitize E. coli to hydrophobic antibiotics such as rifampicin.
