1285572-51-1

Basic information

• Product Name: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone
• Synonyms: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone
• CAS NO: 1285572-51-1
• Molecular Weight: 358.202
• Mol File: 1285572-51-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 188 - 191°C
• Boiling Point: 614.8±55.0 °C(Predicted)
• Density: 1.662±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone(1285572-51-1)
• EPA Substance Registry System: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1λ⁶-1,3-benzothiazol-3-yl)methanone(1285572-51-1)

Safety Data

• Hazardous Substances Data: 1285572-51-1(Hazardous Substances Data)

Usage

Uses

Dotinurad is a useful drug for treating hyperuricemia and gout.

Upstream product

• 3336-41-2 3,5-dichloro-4-hydroxybenzoic acid 
• 4433-53-8 2,3-dihydro-1,1-dioxobenzothiazole 
• 59595-92-5 chlorure de dichloro-3,5 hydroxy-4 benzoyle 
• 1285572-54-4 (3,5-dichloro-4-hydroxyphenyl)-(3-(2H)-benzothiazolyl)methanone 
• 1285573-44-5 3-(3,5-dichloro-4-methoxybenzoyl)-1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole 
• 1285573-42-3 3-(3,5-dichloro-4-methoxybenzoyl)-1,2-dihydro-3H-1,3-benzothiazole 
• 29568-76-1 3,5-Dichloro-4-methoxybenzoyl chloride 
• 137-07-5 2-amino-benzenethiol 
• 37908-97-7 3,5-dichloro-4-methoxybenzoic acid 
• 4433-52-7 2,3-dihydro-benzothiazole 

Relevant articles and documents

Preparation method of dotinurad

The invention discloses a preparation method of dotinurad. According to the preparation method, condensation, cyclization, oxidation and other reactions are conducted in sequence, with 2-aminobenzenemercaptan used as an initial raw material, so the target product dotinurad is obtained. The preparation method has the advantages of easily available raw materials, rapidness, convenience, economic performance, environmental protection performance and suitability for large-scale industrial production.

Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity

To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-

NOVEL PHENOL DERIVATIVE

Disclosed are a novel compound and a pharmaceutical product, each having a remarkable uricosuric effect. Specifically disclosed are: a novel phenol derivative represented by general formula (1) that is shown in FIG. 1; a pharmaceutically acceptable salt t