128576-61-4Relevant articles and documents
Stereoselective synthesis of allele-specific BET inhibitors
Bond, Adam G.,Ciulli, Alessio,Testa, Andrea
, p. 7533 - 7539 (2020)
Developing stereoselective synthetic routes that are efficient and cost-effective allows easy access to biologically active molecules. Our previous syntheses of allele-selective bumped inhibitors of the Bromo and Extra-Terminal (BET) domain proteins, Brd2
Methods for synthesizing amatoxin building block and amatoxins
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Paragraph 0065; 0066; 0067; 0068, (2014/01/23)
The invention relates to novel methods for synthesizing a synthon for γ,δ-dihydroxyisoleucine 1 (CAS No. 55399-94-5] as building block for the synthesis of amatoxins, and for novel methods for synthesizing amatoxins using such building block.
Stereoselective Synthesis of 2,3-Diamino Acids. 2,3-Diamino-4-phenylbutanoic Acid
Dunn, Peter J.,Haener, Robert,Rapoport, Henry
, p. 5017 - 5025 (2007/10/02)
The synthesis of (2S,3S)- and (2S,3R)-2,3-diamino-4-phenylbutanoic acid (1c and 3) from L-aspartic acid is described.The N-(phenylfluorenyl)-protected aspartic acid diesters 4 and 10 (α-tert-butyl, β-methyl), 18 (β-benzyl, α-tert-butyl), and 28 (β-benzyl,