128639-02-1Relevant articles and documents
A aryltriazolinones preparation method
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Paragraph 0042; 0043, (2017/08/25)
The invention discloses a method for preparing aryl triazolinone. The method comprises the following steps: by taking aryl triazolinone as a raw material, taking an oxygen-containing gas or hydrogen peroxide water solution as an oxidant, and taking active carbon as a catalyst, performing oxidation reaction to obtain aryl triazolinone. By adopting the method, a new concept for the synthesis of the aryl triazolinone compound is provided, the hydrogen peroxide solution or the oxygen-containing gas is taken as the oxidant, the active carbon is taken as the catalyst, and the traditional processing modes of hypohalous acid and salt thereof, halogen oxidant or metal compound catalyst are substituted; the halogen and the metal compound are not contained in the wastewater, so that the environment is not polluted; when the optimized active carbon is adopted, the purity and the yield of the product are high. The environment pollution caused by the halogen-containing oxidant and the metal compound is avoided, the production process is clean, the reaction process is environmentally friendly, the product content and the yield are high and the economic and environmental protection benefits are obvious, so that the method is a scientific and environment-friendly novel method for producing the aryl triazolinone compound.
Synthesis method of intermediate [...][...] and
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Paragraph 0040; 0047, (2017/04/06)
The invention discloses a method for synthesizing carfentrazone-ethyl and a carfentrazone-ethyl intermediate. The method comprises the following steps: taking 1-(4-chloro-2-fluorophenyl)-3-methyl-1H-1,2,4-triazole-5-ketone as a raw material; carrying out difluoridate methylation, nitrification, catalytic hydrogenation reduction and diazo arylation to obtain 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxygen-1H-1,2,4-triazole-1-radical]-4-fluorophenyl}propionic acid or carfentrazone-ethyl final product. The method disclosed by the invention has the benefits of simplified integral process, mild reaction conditions, high yield, and high quality of products, thereby facilitating industrial production.
Preparation method of carfentrazone-ethyl
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Paragraph 0034, (2014/02/15)
A preparation method of carfentrazone-ethyl comprises steps of: reacting 1-(5-amino-4-chloro-2-fluorophenyl)-4-difluoromethyl-3-methyl-1H-1,2,4-triazol-5-one with acrylic acid through a diazo arylation reaction to give 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid; and reacting the 2-chloro-3-{2-chloro-5-[4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1H-1,2,3-triazol-1-yl]-4-fluorophenyl}propionic acid with ethanol through an esterification reaction in a presence of an acidic catalyst to give carfentrazone-ethyl.