128650-87-3

Basic information

• Product Name: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid
• Synonyms: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid
• CAS NO: 128650-87-3
• Molecular Weight: 326.309
• Mol File: 128650-87-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid(128650-87-3)
• EPA Substance Registry System: <3-(4'-hydrobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo quinazolin-1-yl> acetic acid(128650-87-3)

Safety Data

• Hazardous Substances Data: 128650-87-3(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 118-48-9 isatoic anhydride 
• 112732-92-0 Ethyl 2-[1,2,3,4-tetrahydro-3-(4-methoxybenzyl)-2,4-dioxoquinazolin-1-yl]acetate 
• 221539-62-4 3-(4-methoxybenzyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline 
• 221539-30-6 2-amino-N-(4-methoxybenzyl)benzamide 

Relevant articles and documents

Aldose reductase inhibition by 2,4-oxo and thioxo derivatives of 1,2,3,4-tetrahydroquinazoline

Inhibitors of aldose reductase are believed to be useful for the treatment of diabetic complications.Original acetic acids and their thioxo derivatives have been synthesized and examined for their ability to inhibit aldose reductase in vitro and in vivo.Most were active in vitro on rat lens aldose reductase in the 10-7 molar range.Compound V16, which has a (2'-fluoro-4'-bromo)benzyl substituent on nitrogen N-3 was found in hypergalactosemic rats to be a good inhibitor of galactitol accumulation in sciatic nerves andto prevent cataract formation.