128654-20-6Relevant articles and documents
A 1,2-diyl process for preparation of carboxylic acid esters
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Paragraph 0027; 0028; 0029; 0030; 0039; 0040; 0041; 0042, (2016/10/17)
The invention discloses a synthetic method of 1, 2-diol dicarboxylic ester. The method comprises the following step: by taking 2,3-dichloro-5, 6-dicyan-1,4-benzoquinone as a dehydrogenation agent, carrying out reaction on cycloacetal and carboxylic acid in a dried organic solvent for 6-48 hours at 20-140 DEG C to obtain 1, 2-diol dicarboxylic ester, wherein the molar ratio of cycloacetal to carboxylic acid is (1-10): 1 and the molar ratio of the dehydrogenation agent to carboxylic acid is (1-10): 1. The method overcomes the defects that in the prior art, a strong acid or an expensive coupling agent is required, monoester needs to be pre-prepared when asymmetrical dicarboxylic ester is synthesized, and 1,2-diol in the process is excessive in amount and the like. The synthetic method has the advantages that 1) by taking 2,3-dichloro-5,6-dicyan-1,4-benzoquinone as the dehydrogenation agent, non-metal coupling is realized, and heavy metal ions are prevented from being left in a product; 2) the reaction product is easy to separate and the dehydrogenation agent is easy to regenerate; 3) the process is simple, the cost is low, the product is good in specificity and environmental-friendly; and 4) the conversion efficiency is high. The synthetic method disclosed by the invention plays an important role in industrial production of 1, 2-diol dicarboxylic ester.
REACTION OF 2-ARYLSUBSTITUTED-1,3-DIOXOLANES WITH ARYLCHLOROCARBENES
Safiev, O. G.,Nazarov, D. V.,Zorin, V. V.,Rakhmankulov, D. L.,Paushkin, Ya. M.
, p. 29 - 32 (2007/10/02)
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