128667-95-8Relevant articles and documents
Synthesis and biological activities of optically active 6-[3-(3,4- Dimethoxybenzylamino)-2-hydroxypropoxy]-2(1H)-quinolinone (OPC-18790)
Fujioka, Takafumi,Teramoto, Shuji,Tsujimi, Sachiko,Takemoto, Kazumi,Mori, Toyoki,Hosokawa, Tetsumi,Sumida, Takumi,Tominaga, Michiaki,Yabuuchi, Youichi
, p. 1596 - 1598 (1996)
The enantiomers of 6-[3-(3,4-dimethoxybenzylamino)-2-hydroxypropoxy]- 2(1H)-quinolinone (OPC-18790), a novel cardiotonic agent, were synthesized and evaluated for positive inotropic activity. The key intermediates, 2,3- epoxypropoxy derivatives, were obtained by the alkylation of 6-hydroxy- 2(1H)-quinolinone with optically active epichlorohydrin and subsequent ring closure. In an in vitro study, the (R)-(+)-isomer was about 10-fold more potent than the (s)-(-)-isomer.