1286756-60-2

Basic information

• Product Name: ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone
• Synonyms: ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone
• CAS NO: 1286756-60-2
• Molecular Weight: 475.35
• Mol File: 1286756-60-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone(1286756-60-2)
• EPA Substance Registry System: ((4R,5S)-5-nitro-4-(2, 4, 5-trifluorophenyl)cyclohex-1-enyl)(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4, 3-a]pyrazin-7(8H)-yl)methanone(1286756-60-2)

Safety Data

• Hazardous Substances Data: 1286756-60-2(Hazardous Substances Data)

Upstream product

• 913623-45-7 1,2,4-trifluoro-5-(2-nitrovinyl)-benzene 
• 1361412-72-7 C₉H₅F₃O 
• 165047-24-5 2,4,5-trifluorobenzaldehyde 
• 1263312-50-0 (E)-3-(2,4,5-trifluorophenyl)acrylaldehyde 
• 882856-63-5 (E)-ethyl-3-(2, 4, 5-trifluorophenyl)acetate 
• 1286756-59-9 (1R,2S)-2',4',5'-trifluoro-2-nitro-1,2,3,6-tetrahydro-[1,1'-biphenyl]-4-carboxylic acid 
• 486460-21-3 3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 
• 1286756-57-7 (4R,5R)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate 
• 1286756-56-6 (R)-4-nitro-3-(2,4,5-trifluorophenyl)butanal 
• 956924-25-7 2-nitro-1-(2,4,5-trifluorophenyl)ethanol 
• 915100-66-2 (E)-1,2,4-trifluoro-5-(2-nitrovinyl)benzene 

Downstream Products

• 913623-70-8 C₂HF₃O₂*C₁₉H₁₇F₆N₅O 

Relevant articles and documents

Asymmetric domino nitro-michael/horner-wadsworth-emmons reaction for disubstituted cyclohexenecarboxylate annulation: Efficient synthesis of dipeptidyl peptidase IV inhibitor ABT-341 and influenza neuraminidase inhibitor

An asymmetric domino nitro-Michael/Horner-Wadsworth-Emmons (HWE) reaction involving α,β-unsaturated aldehydes and nitro phosphonates has been developed, which gave 4,5-disubstituted cyclohexenecarboxylates with high stereoselectivities (dr up to >20:1, ee

One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether

A dream come true: ABT-341 was synthesized in high yield with excellent diastereo- and enantioselectivity in a one-pot process mediated by a diphenylprolinol silyl ether (see scheme; TMS=trimethylsilyl). Thus, an asymmetric Michael reaction, a domino Mich