1286763-64-1

Basic information

• Product Name: (2-methylbutyl)(4-methylphenyl)sulfane
• Synonyms: (2-methylbutyl)(4-methylphenyl)sulfane
• CAS NO: 1286763-64-1
• Molecular Weight: 194.341
• Mol File: 1286763-64-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-methylbutyl)(4-methylphenyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylbutyl)(4-methylphenyl)sulfane(1286763-64-1)
• EPA Substance Registry System: (2-methylbutyl)(4-methylphenyl)sulfane(1286763-64-1)

Safety Data

• Hazardous Substances Data: 1286763-64-1(Hazardous Substances Data)

Upstream product

• 20089-07-0 2-methyl-1-butanethiol 
• 624-31-7 4-tolyl iodide 
• 130900-96-8 C₅H₁₁ClS 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Synthesis of aryl thioethers through the N -chlorosuccinimide-promoted cross-coupling reaction of thiols with Grignard reagents

A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups including ester, fluoro, and chloro are tolerated by the reaction conditions employed. It is important to note that this method has a short reaction time (30 min in total) and represents an alternative approach for the synthesis of aryl sulfides over the existing protocols.

Copper mediated formation of carbon-heteroatom bonds using organoboron reagents and ultrasound

This report summarizes research efforts focused on copper acetate mediated reactions to form new carbon-heteroatom bonds using organoboron reagents under ultrasound irradiation. The method involves the application of ultrasound irradiation to the Chan-Evans-Lam reaction to achieve O-arylation of phenols, N-arylation of anilines and indoles, and S-arylation of thiols. Ultrasound irradiation was found to decrease reaction times from 72 hours to 4 hours while improving the product yields an average of 20%.1 Representative C-O, C-N, and C-S coupling reactions were successfully scaled-up from the milligram to gram levels while maintaining good product yields offering potential applications in industrial processes.

An efficient copper-catalyzed cross-coupling reaction of thiols with aryl iodides

Commercially available Cu2O powder is a very reactive catalyst for the coupling of thiols to aryl iodides. A variety of functional groups including esters, unprotected amines, alcohols, and heterocycles tolerate the reaction conditions. Moreover, di-ortho-substituted aryl iodides with sterically demanding substrates were also coupled to give the desired aryl thioethers in good to excellent yields. Copyright