1287206-15-8Relevant articles and documents
Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake
Jin, Chunyang,Decker, Ann M.,Makhijani, Viren H.,Besheer, Joyce,Darcq, Emmanuel,Kieffer, Brigitte L.,Maitra, Rangan
, p. 6748 - 6758 (2018)
The orphan G-protein-coupled receptor GPR88 is highly expressed in the striatum. Studies using GPR88 knockout mice have suggested that the receptor is implicated in alcohol seeking and drinking behaviors. To date, the biological effects of GPR88 activatio