1287211-10-2

Basic information

• Product Name: (5S)-5-(trifluoroMethyl)-2-Pyrrolidinone
• Synonyms: 5S)-5-(trifluoroMethyl) pyrrolidin-2-one;(5S)-5-(Trifluoromethyl)pyrrolidin-2-one 98%ee;(5S)-5-(trifluoroMethyl)-2-Pyrrolidinone
• CAS NO: 1287211-10-2
• Molecular Formula: C₅H₆F₃NO
• Molecular Weight: 153.1024496
• Mol File: 1287211-10-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98-105°C
• Boiling Point: 220.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.339±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.16±0.40(Predicted)
• CAS DataBase Reference: (5S)-5-(trifluoroMethyl)-2-Pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (5S)-5-(trifluoroMethyl)-2-Pyrrolidinone(1287211-10-2)
• EPA Substance Registry System: (5S)-5-(trifluoroMethyl)-2-Pyrrolidinone(1287211-10-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 1287211-10-2(Hazardous Substances Data)

Usage

Description

(5S)-5-(trifluoroMethyl)-2-Pyrrolidinone, also known as TFMP, is a colorless liquid chemical compound with the molecular formula C5H6F3NO. It is known for its high boiling point, low vapor pressure, and chemical stability under normal conditions. TFMP is soluble in a wide range of organic solvents and is commonly used as a solvent and in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
(5S)-5-(trifluoroMethyl)-2-Pyrrolidinone is used as a solvent and building block in the synthesis of pharmaceuticals for its ability to improve the solubility and stability of active ingredients in various formulations.
Used in Agricultural Industry:
(5S)-5-(trifluoroMethyl)-2-Pyrrolidinone is used as a solvent and building block in the synthesis of agrochemicals for its ability to improve the solubility and stability of active ingredients in various formulations.
Used in Industrial Applications:
(5S)-5-(trifluoroMethyl)-2-Pyrrolidinone is used as a solvent in a variety of industrial applications due to its high boiling point, low vapor pressure, and chemical stability.

Upstream product

• 98-79-3 L-Pyroglutamic acid 

Downstream Products

• 119580-41-5 (S)-(+)-2-(trifluoromethyl)pyrrolidine 

Relevant articles and documents

Modulating NHC catalysis with fluorine

Fluorination often confers a range of advantages in modulating the conformation and reactivity of small molecule organocatalysts. By strategically introducing fluorine substituents, as part of a β-fluoroamine motif, in a triazolium pre-catalyst, it was possible to modulate the behaviour of the corresponding N-heterocyclic carbene (NHC) with minimal steric alterations to the catalyst core. In this study, the effect of hydrogen to fluorine substitution was evaluated as part of a molecular editing study. X-ray crystallographic analyses of a number of derivatives are presented and the conformations are discussed. Upon deprotonation, the fluorinated triazolium salts generate catalytically active N-heterocyclic carbenes, which can then participate in the enantioselective Steglich rearrangement of oxazolyl carbonates to C-carboxyazlactones (e.r. up to 87.0:13.0).

PRODUCTION METHOD OF OPTICALLY ACTIVE FLUORINE-CONTAINING AMINO ACID

PROBLEM TO BE SOLVED: To provide a production method of optically active fluorine-containing amino acids useful as a synthetic intermediate of pharmaceutical and agricultural chemicals. SOLUTION: Optically active fluorine-containing amino acids expressed by general formula (4) or general formula (5) are obtained by a radical addition reaction of a halocarboxylic acid ester to an optically active trifluoromethyl tert-butyl sulfine imide. In formula (4), R1 represents a methyl group, an ethyl group or a linear, branched or cyclic alkyl group having 3 to 4 carbon atoms; X represents a halogen atom; and n represents an integer of 1 to 5. In formula (5), R1 and n are the same as defined above. COPYRIGHT: (C)2015,JPOandINPIT