128759-76-2 Usage
Derivation
A synthetic derivative of vincamine, a natural alkaloid found in the leaves of the Vinca minor plant.
Type of Compound
A prodrug, which means it is converted into its active form in the body.
Active Metabolite
Once metabolized, it releases nitric oxide, a molecule that relaxes and dilates blood vessels.
Medical Use
Has shown potential in the treatment of various conditions, including dementia, Alzheimer's disease, and stroke.
Mechanism of Action
Improves cognitive function and increases cerebral blood flow by relaxing and dilating blood vessels.
Benefits
Enhances cognitive function and improves blood flow to the brain and other parts of the body.
Check Digit Verification of cas no
The CAS Registry Mumber 128759-76-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,7,5 and 9 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128759-76:
(8*1)+(7*2)+(6*8)+(5*7)+(4*5)+(3*9)+(2*7)+(1*6)=172
172 % 10 = 2
So 128759-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H25N3O5/c1-2-22-9-5-10-23-11-8-16-15-6-3-4-7-17(15)24(19(16)20(22)23)18(14-22)21(26)29-12-13-30-25(27)28/h3-4,6-7,14,20H,2,5,8-13H2,1H3/t20-,22+/m1/s1
128759-76-2Relevant articles and documents
Synthesis and Pharmacological Evaluation of (Nitrooxy)alkyl Apovincaminates
Kawashima, Yutaka,Ikemoto, Tomoyuki,Horiguchi, Akiyo,Hayashi, Masatoshi,Matsumoto, Keita,et al.
, p. 815 - 819 (1993)
A series of (nitrooxy)alkyl apovincaminates has been synthesized and evaluated for their effects on vertebral and femoral blood flow.These derivatives were prepared from apovincaminic acid (4).In cerebral circulation, compound 5 (0.03-1.0 mg/kg iv) caused a dose-dependent increase in cerebral blood flow (CerBF) without affecting the blood pressure.It was more potent than vinpocetine (2).The structures of 2 and 5, determined by X-ray crystallography, showed differences in the electrostatic potential image and in the conformation of the ethyl group at the 16-position.
