128781-80-6

Basic information

• Product Name: BOC-3,5-DIIODO-TYR-OME
• Synonyms: N-ALPHA-T-BUTOXYCARBONYL-3,5-DIIODO-L-TYROSINE METHYL ESTER;BOC-3,5-DIIODO-TYROSINE-OME;BOC-3,5-DIIODO-TYR-OME;BOC-3,5-DIIODO-L-TYROSINE METHYL ESTER;BOC-TYR(3,5-I2)-OME;Boc-3,5-diiodo-L-Tyr-OMe;Boc-3,5-diiodo-L-tyrosine methyl ester≥ 98% (HPLC)
• CAS NO: 128781-80-6
• Molecular Formula: C₁₅H₁₉I₂NO₅
• Molecular Weight: 547.12
• Mol File: 128781-80-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 494.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.844±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 6.90±0.25(Predicted)
• CAS DataBase Reference: BOC-3,5-DIIODO-TYR-OME(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-3,5-DIIODO-TYR-OME(128781-80-6)
• EPA Substance Registry System: BOC-3,5-DIIODO-TYR-OME(128781-80-6)

Safety Data

• Hazardous Substances Data: 128781-80-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Upstream product

• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 300-39-0 3,5-diiodo-l-tyrosine 
• 62129-53-7 (tert-butoxycarbonyl)-3,5-diiodotyrosine 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 1080-06-4 L-Tyr-OMe 
• 60-18-4 L-tyrosine 
• 76318-50-8 3,5-diiodo-L-thyrosine methyl ester 

Downstream Products

• 178666-09-6 (S)-2-tert-Butoxycarbonylamino-3-{4-[2-(4-hydroxy-phenyl)-ethoxy]-3,5-diiodo-phenyl}-propionic acid methyl ester 
• 205812-29-9 (S)-2-tert-Butoxycarbonylamino-3-{4-[2-(3-{2-[4-((S)-2-tert-butoxycarbonylamino-2-carboxy-ethyl)-2,6-diiodo-phenoxy]-ethyl}-2-oxo-imidazolidin-1-yl)-ethoxy]-3,5-diiodo-phenyl}-propionic acid 
• 128781-78-2 C₅₃H₅₂I₄N₈O₅ 
• 128802-36-8 C₄₉H₆₀I₄N₈O₁₁ 
• 1016161-86-6 C₃₃H₄₇I₂NO₆Si 
• 1016161-88-8 C₃₁H₄₅I₂NO₆Si 
• 1016161-89-9 C₃₂H₄₇I₂NO₆Si 
• 1016161-90-2 C₃₁H₄₅I₂NO₇Si 
• 1016161-91-3 C₃₀H₄₃I₂NO₆Si 
• 579525-48-7 N-t-butoxycarbonyl-3,5-dimethyl-L-tyrosine methyl ester 
• 62129-53-7 (tert-butoxycarbonyl)-3,5-diiodotyrosine 
• 113850-74-1 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-diiodo-4-methoxyphenyl)propanoate 
• 1417654-56-8 (S)-2-((tert-butoxycarbonyl)amino)-3-(3,5-diiodo-4-(4-methoxy-3-methylphenoxy)phenyl)propanoic acid 
• 1417654-58-0 (S)-2-amino-3-(3,5-diiodo-4-(4-methoxy-3-methylphenoxy)phenyl)propan-1-ol 

Relevant articles and documents

COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF

Provided are a compound including a cleavable linker, a use thereof, and an intermediate compound for preparing the same, and more particularly, the compound including a cleavable linker of the present invention may include an active agent (for example, a drug, a toxin, a ligand, a probe for detection, etc.) having a specific function or activity, a SO2 functional group which is capable of selectively releasing the active agent, and a functional group which triggers a chemical reaction, a physicochemical reaction and/or a biological reaction by external stimulation, and may further include a ligand (for example, oligopeptide, polypeptide, antibody, etc.) having binding specificity for a desired target receptor.

The synthesis of 13C9-15N-labeled 3,5-diiodothyronine and thyroxine

Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.

Tyrosine-based poly(m-phenyleneethynylene-p-phenyleneethynylene)s. Helix folding and responsiveness to a base

The Sonogashira-Hagihara polymerization of 3',5'-diiodo-N-α-tert-butoxycarbonyl-l-tyrosine methyl ester (1) and 3',5'-diiodo-N-α-tert-butoxycarbonyl-O-methyl-l-tyrosine methyl ester (2) with para-diethynylbenzene (3) was carried out to obtain optically active poly(m-phenyleneethynylene-p-phenyleneethynylene)s [poly(1) and poly(2)] with Mn's ranging from 9900 to 15,000 in 80-87% yields. Poly(1) exhibited intense CD signals in DMSO and THF, but did not in CH2Cl2, indicating that it took a predominantly one-handed helical conformation in the former two solvents. On the other hand, there was no evidence for poly(2) to take a helical structure in these solvents. Poly(1) turned the CD sign at 390 nm from plus to minus in DMSO/H2O = 9/1 (v/v) by the addition of NaOH. Alkaline hydrolysis of ester moieties of poly(1) and poly(2) gave the corresponding polymers having carboxy groups [poly(1a) and poly(2a)]. Poly(1a) and poly(2a) increased the CD intensity by the addition of NaOH.