128892-33-1

Basic information

• Product Name: -N-methyl-L-valine methyl ester
• Synonyms: -N-methyl-L-valine methyl ester
• CAS NO: 128892-33-1
• Molecular Weight: 392.495
• Mol File: 128892-33-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: -N-methyl-L-valine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: -N-methyl-L-valine methyl ester(128892-33-1)
• EPA Substance Registry System: -N-methyl-L-valine methyl ester(128892-33-1)

Safety Data

• Hazardous Substances Data: 128892-33-1(Hazardous Substances Data)

Upstream product

• 53363-91-0 2-(N-benzyloxycarbonyl-N-methylamino)-3-methylbutyric acid methyl ester 
• 42417-65-2 Z-MeVal-OH 
• 3339-44-4 methyl N-methyl-L-valinate hydrochloride 
• 53978-73-7 Z-D-MeVal 

Relevant articles and documents

A novel thiazolium type peptide coupling reagent for hindered amino acids

A highly efficient coupling reagent, 2-bromo-3-ethyl-4-methyl thiazolium tetrafluoroborate (BEMT), was designed, synthesized and successfully applied to the synthesis of oligopeptides containing N-alkyl or α-C-dialkyl amino acids. Its efficiency was evaluated by HPLC and 1H NMR methods, and demonstrated by synthesis of a number of N-methyl-rich peptide segments with good yields and negligible racemization. The mechanism of coupling was studied by HPLC, 1H NMR and IR monitoring; it is proposed that labile (acyloxy)thiazolium salts and N-protected amino acid bromides were the major active intermediates with concomitant formation of N-ethyl-4-methyl thiazolidones and a small amount of oxazolones and N-protected amino acid anhydrides.

BroP: A new reagent for coupling N-methylated amino acids

BroP (bromo tris(dimethylamino) phosphonium hexafluorophosphate) is a particularly suitable reagent for coupling N-methylated amino acids. It is stable and gives very high yields in short reaction times. Dipeptides are obtained without appreciable epimeri