1289108-81-1

Basic information

• Product Name: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate
• CAS NO: 1289108-81-1
• Molecular Weight: 572.59
• Mol File: 1289108-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate(1289108-81-1)
• EPA Substance Registry System: tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate(1289108-81-1)

Safety Data

• Hazardous Substances Data: 1289108-81-1(Hazardous Substances Data)

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 352-13-6 4-flourophenylmagnesium bromide 
• 79419-73-1 (RS)-3-(4-fluorophenyl)-3-hydroxy-indolin-2-one 
• 91-56-5 indole-2,3-dione 
• 282549-48-8 3-(4-fluorophenyl)indolin-2-one 
• 136918-14-4 phthalimide 
• 862907-06-0 tert-butyl 3-(4-fluorophenyl)-2-oxoindoline-1-carboxylate 
• 24249-89-6 ethyl 2-(1,3-dioxoisoindolin-2-yl)acrylate 

Relevant articles and documents

Facile synthesis of enantioenriched Cγ-tetrasubstituted α-amino acid derivatives via an asymmetric nucleophilic addition/protonation cascade

Chemical equations presented. An asymmetric nucleophilic addition/protonation reaction of 3-substituted oxindoles and ethyl 2-phthalimidoacrylate has been described. This strategy can give direct access to Cγ-tetrasubstituted α-amino acid derivatives bearing 1,3-nonadjacent stereocenters with up to 98% yield, 94:6 dr, and >99% ee. Dual activation is proposed in the transition state, and the opposite enantiomers can be obtained simply by changing cinchonidine-derived catalyst to the cinchonine analogue.