129001-06-5

Basic information

• Product Name: (R)-2-Chlorocarbonyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester
• CAS NO: 129001-06-5
• Molecular Weight: 287.787
• Mol File: 129001-06-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Chlorocarbonyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Chlorocarbonyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester(129001-06-5)
• EPA Substance Registry System: (R)-2-Chlorocarbonyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester(129001-06-5)

Safety Data

• Hazardous Substances Data: 129001-06-5(Hazardous Substances Data)

Upstream product

• 129001-05-4 C₁₇H₂₇NO₄S₂ 
• 125736-06-3 (1R,2R)- and (1R,2S)-9-(tert-butoxycarbonyl)-2-(methoxycarbonyl)-9-azabicyclo<4.2.1>nonane 
• 125736-03-0 (R)-9-Aza-bicyclo[4.2.1]nonane-2,9-dicarboxylic acid 9-tert-butyl ester 

Downstream Products

• 90741-49-4 (R)-2-Acetyl-9-aza-bicyclo[4.2.1]nonane-9-carboxylic acid tert-butyl ester 

Relevant articles and documents

Enantiodivergent Synthesis of (+)- and (-)-Anatoxin from L-Glutamic acid

The optically pure 2,5-difunctionalized homotropane 11, prepared from L-glutamic acid, serves as the common, advanced intermediate for the synthesis of either natural (+)-anatoxin (30, 18percent overall yield) or unnatural (-)-anatoxin (33, 30percent overall yield) by selective manipulation of either the C-2 ester or C-5 acetyl functionalities.Side-chain substitution in the decarbonylative iminium ion cyclization of a substituted proline enhanced the yield by 25percent as compared to the unsubstituted parent system.The additional substitution at C-5 of the 9-azabicyclononane ring system allows access to analogues of anatoxin not availalble through other syntheses.