1290056-79-9

Basic information

• Product Name: tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate
• Synonyms: tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate
• CAS NO: 1290056-79-9
• Molecular Weight: 490.643
• Mol File: 1290056-79-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate(1290056-79-9)
• EPA Substance Registry System: tert-butyl N-[[3-[1-[3-(2-cyclobutylideneethoxy)benzoyl]-4-piperidyl]phenyl]methyl]carbamate(1290056-79-9)

Safety Data

• Hazardous Substances Data: 1290056-79-9(Hazardous Substances Data)

Upstream product

• 1290056-77-7 methyl 3-(2-cyclobutylideneethoxy)benzoate 
• 4415-76-3 α-(hydroxymethyl)methylenecyclobutane 
• 150255-96-2 (3‐cyanophenyl)boronic acid 
• 6952-59-6 3-cyanobromobenzene 
• 1290056-78-8 3-(2-cyclobutylideneethoxy)benzoic acid 
• 725228-49-9 tert-butyl 3-(piperidin-4-yl)benzylcarbamate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 27741-65-7 α-(ethoxycarbonyl)methylenecyclobutane 
• 286961-24-8 benzyl 1,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 19438-10-9 methyl 3-hydroxybenzoate 

Downstream Products

• 1290056-80-2 tert-butyl N-[[3-[1-[3-[2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate 
• 1290053-86-9 (4-(3-(aminomethyl)phenyl)piperidin-1-yl)(3-(2-hydroxy-2-(1-hydroxycyclobutyl)ethoxy)phenyl)methanone 
• 1431546-81-4 tert-butyl N-[[3-[1-[3-[2-(1-hydroxycyclobutyl)-2-oxo-ethoxy]benzoyl]-4-piperidyl]phenyl]methyl]carbamate 

Relevant articles and documents

Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two active sites potently inhibit this configuration, but these large compounds have poor drug-like properties. To overcome some of these challenges, we developed self-assembling molecules, called coferons, which deliver a larger compound in two parts. Using a pharmacophoric core and reversibly binding linkers to span two active sites, we have successfully produced three novel homodimeric tryptase inhibitors. Upon binding to tryptase, compounds reassembled into flexible homodimers, with significant improvements in IC50 (0.19 ± 0.08 μM) over controls (5.50 ± 0.09 μM), and demonstrate good activity in mast cell lines. These studies provide validation for this innovative technology that is especially well-suited for the delivery of dimeric drugs to modulate intracellular macromolecular targets.

COFERONS AND METHODS OF MAKING AND USING THEM

The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore.