1290637-13-6

Basic information

• Product Name: 5-methyl-6-(2-thienylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Synonyms: 5-methyl-6-(2-thienylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• CAS NO: 1290637-13-6
• Molecular Weight: 238.334
• Mol File: 1290637-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-6-(2-thienylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-6-(2-thienylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(1290637-13-6)
• EPA Substance Registry System: 5-methyl-6-(2-thienylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(1290637-13-6)

Safety Data

• Hazardous Substances Data: 1290637-13-6(Hazardous Substances Data)

Upstream product

• 4756-05-2 thioacetone 
• 1290637-17-0 ethyl 2-methyl-3-oxo-4-(thiophen-2-yl)butanoate 

Downstream Products

• 1290637-16-9 5-methyl-6-(2-thienylmethyl)-2-{[(phenylsulfanyl)methyl]sulfanyl}pyrimidin-4(3H)-onepyrimidin-4(1H)-one 

Relevant articles and documents

Synthesis and studies of new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-ones as possible HIV-1 reverse transcriptase inhibitors

Six new 6-[halo(diphenyl)methyl]- and 6-(thiophen-2-ylmethyl)pyrimidin- 4(3H)-one derivatives were synthesized and studied for biological activity. The studies showed that the 6-(thiophen-2-ylmethyl)pyrimidin-4(3H)-one derivatives inhibited activity of the HIV-1 recombinant reverse transcriptase in the micromolar range of concentrations. The 6-[halo-(diphenyl)methyl]pyrimidin-4(3H) -one derivative showed no activity in the concentrations up to 200 μmol mL-1.