129097-92-3

Basic information

• Product Name: 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline
• Synonyms: 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline
• CAS NO: 129097-92-3
• Molecular Weight: 180.001
• Mol File: 129097-92-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline(129097-92-3)
• EPA Substance Registry System: 3-bromo-5-(hydroxymethyl)-Δ²-isoxazoline(129097-92-3)

Safety Data

• Hazardous Substances Data: 129097-92-3(Hazardous Substances Data)

Upstream product

• 13146-23-1 copper(I) phenylacetylenide 
• 74213-24-4 N-dibromomethylidenehydroxylamine 
• 107-18-6 allyl alcohol 

Downstream Products

• 128993-09-9 (RS)-3-benzyloxy-5-(hydroxymethyl)-Δ²-isoxazoline 
• 128993-18-0 (5R)-3-Bromo-5-hydroxymethyl-Δ²-isoxazoline 
• 128993-17-9 (5S)-3-Bromo-5-hydroxymethyl-Δ²-isoxazoline 
• 140384-88-9 Butyric acid (R)-3-bromo-4,5-dihydro-isoxazol-5-ylmethyl ester 
• 140384-87-8 Butyric acid (S)-3-bromo-4,5-dihydro-isoxazol-5-ylmethyl ester 
• 83527-35-9 S-3,4-dihydroxy butyronitrile 
• 918440-90-1 ((S)-3-bromo-4,5-dihydroisoxazol-5-yl)methyl acetate 
• 152611-10-4 (S)-2-Cyclohexyl-5-hydroxymethyl-isoxazolidin-3-one 

Relevant articles and documents

Palladium-free Sonogashira-type cross-coupling reaction of bromoisoxazolines or N-alkoxyimidoyl bromides and alkynes

A Cu(I)-catalysed Sonogashira-type cross coupling reaction with aliphatic or aromatic bromoisoxazolines or N-alkoxyimidoyl bromides and alkynes is reported. The protocol we developed employs catalytic amount of copper(I), non-toxic ligand bathophenanthroline and is tolerant to a wide range of functional groups and is therefore particulary adapted in the context of drug discovery.

The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds

Target analysis of acivicin derived 3-halodihydroisoxazoles scaffolds in living non-pathogenic and pathogenic bacteria.

BROMONITRILE OXIDE CYCLOADDITIONS IN WATER

Bromonitrile oxide can be generated homogeneously in water at acidic pH, allowing efficient cycloaddition with water soluble olefins and acetylenes.Allylammonium salts react with high regioselectivity and without the need for N-group protection. Keyword: Acivicin; transglutaminase; cysteine; 4,5-dihydroisoxazole; dibromonoformaldoxime.