1291779-97-9

Basic information

• Product Name: (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]-N-methyl-amide
• CAS NO: 1291779-97-9
• Molecular Weight: 390.485
• Mol File: 1291779-97-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]-N-methyl-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]-N-methyl-amide(1291779-97-9)
• EPA Substance Registry System: (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid N-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]-N-methyl-amide(1291779-97-9)

Safety Data

• Hazardous Substances Data: 1291779-97-9(Hazardous Substances Data)

Upstream product

• 71830-08-5 (1R,3S)-3-aminocyclopentanecarboxylic acid 
• 139705-74-1 2-(4-aminophenyl)imidazo<1,2-a>pyridine 
• 1291779-68-4 (1R,3S)-3-propionylamino-cyclopentanecarboxylic acid 
• 497848-13-2 4-(indolizin-2-yl)-N-methylbenzeneamine 
• 1291779-71-9 N-(4-(imidazo[1,2-a]pyridin-2-yl)-phenyl)-N-methyl-2,2,2-trifluoroacetamide 
• 1291779-70-8 N-(4-(imidazo[1,2-a]pyridin-2-yl)-phenyl)-2,2,2-trifluoroacetamide 

Relevant articles and documents

Discovery of BI 99179, a potent and selective inhibitor of type i fatty acid synthase with central exposure

Based on a high-throughput screen, cyclopentanecarboxanilides were identified as a new chemotype of non-covalent inhibitors of type I fatty acid synthase (FAS). Starting from initial hits we aimed at generating a tool compound suitable for the in vivo validation of FAS as a therapeutic target. Optimisation yielded BI 99179 which is characterised by high potency, remarkably high selectivity and significant exposure (both peripheral and central) upon oral administration in rats.