129247-67-2

Basic information

• Product Name: 1-[(4-Methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol
• Synonyms: 1-[(4-Methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol
• CAS NO: 129247-67-2
• Molecular Weight: 348.442
• Mol File: 129247-67-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[(4-Methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-Methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol(129247-67-2)
• EPA Substance Registry System: 1-[(4-Methoxy-phenyl)-diphenyl-methoxy]-propan-2-ol(129247-67-2)

Safety Data

• Hazardous Substances Data: 129247-67-2(Hazardous Substances Data)

Upstream product

• 4254-15-3 (S)-1,2-Propanediol 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 57-55-6 propylene glycol 
• 1881-93-2 (4-methoxyphenyl)diphenylmethylium tetrafluoroborate 

Downstream Products

• 138247-73-1 (R)-2-O-<(diisopropylphosphono)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>-1,2-propanediol 

Relevant articles and documents

Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors

Lysophosphatidylserine (LysoPS), an endogenous ligand of G protein-coupled receptors, consists of l-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages, respectively. An ester linkage of phosphatidylserine can be hydrolyzed at the 1-position or at the 2-position to give 2-acyl lysophospholipid or 1-acyl lysophospholipid, respectively. 2-Acyl lysophospholipid is in nonenzymatic equilibrium with 1-acyl lysophospholipid in vivo. On the other hand, 3-acyl lysophospholipid is not found, at least in mammals, raising the question of whether the reason for this might be that the 3-acyl isomer lacks the biological activities of the other isomers. Here, to test this idea, we designed and synthesized a series of new 3-acyl lysophospholipids. Structure-activity relationship studies of more than 100 "glycol surrogate"derivatives led to the identification of potent and selective agonists for LysoPS receptors GPR34 and P2Y10. Thus, the non-natural 3-acyl compounds are indeed active and appear to be biologically orthogonal with respect to the physiologically relevant 1-and 2-acyl lysophospholipids.

4,4'-Dimethoxytrityl and 4-Monomethoxytrityl Tetrafluoroborate: Convenient Reagents for the Protection of Primary Alcohols Including Sugars

In a non-donor solvent (e.g. acetonitrile) and in the presence of 2,6-di-t-butyl-4-methylpyridine, the readily prepared 4-methoxytrityl tetrafluoroborate (3) and 4,4'-dimethoxytrityl tetrafluoroborate (2) are highly effective reagents for the methoxytritylation and dimethoxytritylation, respectively, of primary alcohols including sugars.