129271-99-4

Basic information

• Product Name: Benzenesulfonamide, N-(2-acetylphenyl)-
• CAS NO: 129271-99-4
• Molecular Formula: C14H13NO3S
• Molecular Weight: 275.328
• Mol File: 129271-99-4.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-acetylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-acetylphenyl)-(129271-99-4)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-acetylphenyl)-(129271-99-4)

Safety Data

• Hazardous Substances Data: 129271-99-4(Hazardous Substances Data)

Upstream product

• 4127-53-1 3-methylbenzo[c]isoxazole 
• 873-55-2 sodium benzenesulfonate 
• 16714-26-4 1-(2-azido-phenyl)-ethanone 
• 98-09-9 benzenesulfonyl chloride 
• 551-93-9 2-aminoacetophenone 
• 938-10-3 phenylsulfonyl azide 
• 98-86-2 acetophenone 

Downstream Products

• 144221-12-5 (E)-3-(4-methoxyphenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one 

Relevant articles and documents

C-to N-Center Remote Heteroaryl Migration via Electrochemical Initiation of N Radical by Organic Catalyst

Herein an exogenous oxidant- A nd metal-free electrochemical heteroaryl migration triggered by N radicals to construct new N-C bonds was developed. This methodology features a high atom economy and utilization rate of energy, and it is insensitive to water and air. Moreover, a user-friendly undivided cell was employed. The use of an organic catalyst makes it more efficient, green, and practical.

Sulphonamide chalcones: Conformationally diverse yet optically similar

In this paper, we present the synthesis of three chalcone analogues and their spectroscopic, structural and optical characterization. The influence of the different substituents on the crystalline structure and on their optical properties was evaluated. T

Synthesis, characterization and evaluation of in vitro antitumor activities of novel chalcone-quinolinone hybrid compounds

Chalcone-quinolinone hybrid compounds, as well as the synthesis of such compounds, have few reports in the literature. Such compounds may be quite useful in therapeutics, since various biological activities are reported for both chalcones and quinolinones. In the present work, several novel chalcone-quinolinone compounds have been synthesized. The reaction conditions developed allowed to obtain the compounds in a single step of synthesis from the chalcones. The products precipitated pure and were isolated by filtration. The yields of such reactions, from 45 to 94percent, were promising. The product structures were confirmed by nuclear magnetic resonance (NMR) and electrospray ionization mass spectrometry (ESI-MS) techniques. Their antitumor activities were evaluated in HCT-116 (colon) cell lines by the 3-(4,5-dimethyl-2-thiazole)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) test. The half maximal inhibitory concentration (IC50) values obtained for the most active chalcones were between 2.9 and 7.5 and for active quinolinone was 19.3 mg L-1. The antitumor activities results suggest that the class of compounds studied has potential for use in cancer research.

Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils

A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.