1292765-18-4 Usage
Description
JWH 398, also known as an exempt preparation, is a synthetic cannabimimetic indole derivative that functions as a dual agonist for cannabinoid receptors CB1 and CB2. As an analytical reference standard, it falls under the category of synthetic cannabinoids. Regulated as a Schedule I compound in the United States, JWH 398 is available as a DEA exempt preparation, primarily intended for research and forensic applications.
Uses
Used in Pharmaceutical Research:
JWH 398 is used as a research compound for the development of new drugs targeting the cannabinoid receptors CB1 and CB2. Its agonistic properties allow scientists to study the effects and potential therapeutic applications of modulating these receptors in various conditions.
Used in Forensic Applications:
In the field of forensic science, JWH 398 serves as a reference standard for the identification and analysis of synthetic cannabinoids in biological samples, such as blood or urine. This aids in the detection and quantification of these substances in cases of drug abuse or intoxication.
Used in Drug Development:
JWH 398 is utilized as a lead compound in the development of novel therapeutic agents that target the CB1 and CB2 receptors. This can potentially lead to the creation of new medications for the treatment of various disorders, including pain management, inflammation, and neurodegenerative diseases.
Used in Toxicological Studies:
JWH 398 is employed in toxicological research to evaluate the safety and potential side effects of synthetic cannabinoids. This helps in understanding the risks associated with their use and contributes to the development of safer and more effective cannabinoid-based therapies.
Used in Analytical Chemistry:
As an analytical reference standard, JWH 398 is used in the calibration of analytical instruments and methods for the detection and quantification of synthetic cannabinoids in various matrices. This ensures accurate and reliable measurements in research and forensic investigations.
Check Digit Verification of cas no
The CAS Registry Mumber 1292765-18-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,9,2,7,6 and 5 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1292765-18:
(9*1)+(8*2)+(7*9)+(6*2)+(5*7)+(4*6)+(3*5)+(2*1)+(1*8)=184
184 % 10 = 4
So 1292765-18-4 is a valid CAS Registry Number.
1292765-18-4Relevant articles and documents
Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: Steric and electronic effects of 4- and 8-halogenated naphthoyl substituents
Wiley, Jenny L.,Smith, Valerie J.,Chen, Jianhong,Martin, Billy R.,Huffman, John W.
, p. 2067 - 2081 (2012/06/01)
To develop SAR at both the cannabinoid CB1 and CB2 receptors for 3-(1-naphthoyl)indoles bearing moderately electron withdrawing substituents at C-4 of the naphthoyl moiety, 1-propyl and 1-pentyl-3-(4-fluoro, chloro, bromo and iodo-1-naphthoyl) derivatives were prepared. To study the steric and electronic effects of substituents at the 8-position of the naphthoyl group, the 3-(4-chloro, bromo and iodo-1-naphthoyl)indoles were also synthesized. The affinities of both groups of compounds for the CB1 and CB2 receptors were determined and several of them were evaluated in vivo in the mouse. The effects of these substituents on receptor affinities and in vivo activity are discussed and structure-activity relationships are presented. Although many of these compounds are selective for the CB2 receptor, only three JWH-423, 1-propyl-3-(4-iodo-1-naphthoyl)indole, JWH-422, 2-methyl-1-propyl-3-(4-iodo-1-naphthoyl)indole, the 2-methyl analog of JWH-423 and JWH-417, 1-pentyl-3-(8-iodo-1-naphthoyl)indole, possess the desirable combination of low CB1 affinity and good CB2 affinity.
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