129288-39-7

Basic information

• Product Name: FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE
• Synonyms: FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE;fmoc-L-glutamic acid 5-tert-butyl ester N-carboxy anhydride;FMOC-GLUTAMIC ACID 5-TERBUTYL ESTER NCA;(S)-(9H-fluoren-9-yl)methyl 4-(3-tert-butoxy-3-oxopropyl)-2,5-dioxooxazolidine-3-carboxylate
• CAS NO: 129288-39-7
• Molecular Formula: C25H25NO7
• Molecular Weight: 451.473
• Mol File: 129288-39-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE(129288-39-7)
• EPA Substance Registry System: FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE(129288-39-7)

Safety Data

• Hazardous Substances Data: 129288-39-7(Hazardous Substances Data)

Usage

General Description

FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE is a chemical compound used in solid-phase peptide synthesis. It is an anhydride derivative of the amino acid glutamic acid, and it contains a fluorenylmethyloxycarbonyl (FMOC) protecting group, as well as an ortho-tert-butyl oxycarbonyl (OTBU) protecting group. FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE is used for the efficient and selective N-terminal protection and activation of amino acids during peptide synthesis, allowing for the stepwise assembly of peptide chains. The FMOC-GLU(OTBU)-N-CARBOXYANHYDRIDE facilitates the formation of peptide bonds and is commonly used in peptide chemistry to synthesize various peptides and proteins for research, pharmaceutical, and biotechnological applications.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 86409-29-2 γ-tert-butyl-l-glutamic acid N-carboxyanhydride 

Downstream Products

• 153815-59-9 4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-hydroxy-pentanoic acid tert-butyl ester 

Relevant articles and documents

Urethane-protected amino acid N-carboxy anhydrides and their use in peptide synthesis

-