129486-41-5

Basic information

• Product Name: 4-(3-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole
• Synonyms: 4-(3-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole
• CAS NO: 129486-41-5
• Molecular Weight: 273.334
• Mol File: 129486-41-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(129486-41-5)
• EPA Substance Registry System: 4-(3-fluorophenyl)-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(129486-41-5)

Safety Data

• Hazardous Substances Data: 129486-41-5(Hazardous Substances Data)

Upstream product

• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 
• 53631-18-8 2-bromo-1-(3-fluorophenyl)ethanone 
• 124583-55-7 4(5)-methyl-5(4)-<(thioacetamido)methyl>imidazole hydrochloride 

Relevant articles and documents

Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5-HT3 Receptor Antagonists

A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described.The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system.An optimized member of this series, 4-(2-methoxyphenyl)-2-methyl>thiazole (5), exhibits oral activity in the Bezold-Jarisch reflex paradigm comparable to or better than the standard agents ondansetron (1) and ICS-205-930 (2).Several of the structure-activity relationships are rationalized in terms of a computer pharmacophore model for 5-HT3 receptor binding.