129527-97-5

Basic information

• Product Name: 1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile
• Synonyms: 1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile
• CAS NO: 129527-97-5
• Molecular Weight: 183.253
• Mol File: 129527-97-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile(129527-97-5)
• EPA Substance Registry System: 1,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbonitrile(129527-97-5)

Safety Data

• Hazardous Substances Data: 129527-97-5(Hazardous Substances Data)

Upstream product

• 1632352-26-1 (R)-2-bromocyclohex-2-en-1-yl diethyl phosphate 
• 1542147-91-0 (R)-2-bromocyclohex-2-en-1-yl picolinate 
• 61426-49-1 (1R)-2-bromocyclohex-2-en-1-ol 
• 50870-61-6 2-bromocyclohex-2-en-1-one 
• 930-68-7 cyclohexenone 
• 1542147-92-1 (S)-6-bromo-1,2,3,4-tetrahydro-1,1'-biphenyl 
• 129527-95-3 1-Nitromethyl-6-phenylcyclohexene 
• 28469-48-9 6-hydroxy-1-cyclohexene-1-carbonitrile 
• 130251-99-9 6-acetoxy-1-cyclohexene-1-carbonitrile 
• 108-86-1 bromobenzene 
• 1855-63-6 cyclohex-1-enecarbonitrile 
• 71-43-2 benzene 
• 129548-54-5 6-Phenyl-cyclohex-1-enecarbaldehyde oxime 

Downstream Products

• 81807-66-1 phenyl(2,3,4,5-tetrahydro-[1,1'-biphenyl]-2-yl)methanone 
• 807351-72-0 2-phenyl-cyclohex-1-enecarboxylic acid amide 
• 108299-04-3 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylic acid 
• 408318-36-5 2-phenylcyclohex-1-ene-1carbonitrile 

Relevant articles and documents

Catalytic C-H bond activation-asymmetric olefin coupling reaction: The first example of asymmetric Fujiwara-Moritani reaction catalyzed by chiral palladium(II) complexes 1

The first example of the asymmetric Fujiwara-Moritani reaction catalyzed by chiral Pd(II) complexes is reported to represent a catalytic aromatic C-H bond activation-asymmetric olefin coupling reaction.

Efficient palladium-catalyzed nucleophilic addition of triorganoindium reagents to carbocyclic derivatives

Palladium (0)-catalyzed allylic substitution reactions employing triorganoindium reagents have been investigated. In situ generated vinyl- and arylindiums react with substituted and unsubstituted cyclohex-2-enyl esters in the presence of 1-3 mol % Pd2(dba)3 to produce vinyl- or arylcyclohexenes in moderate to excellent yields. The stereoselectivity of this process was also examined, and evidence is presented that the reaction proceeds with inversion of stereochemical configuration.

SUBSTITUTION NUCLEOPHILE D'ACETATES DE CYCLENOLS ALLYLIQUES FONCTIONNELS PAR DES ORGANOMETALLIQUES EN PRESENCE DE SELS CUIVREUX. APPLICATION A UNE SYNTHESE RAPIDE DE LA (+/-) MITSUGASHIWALACTONE

Substitution of functional allylic cycloalkenol acetates by Grignard reagents (primary, secondary, tertiary-alkyl, vinyl, aryl) in the presence of a catalytic amount (2.5percent equivalent) of cuprous iodide at low temperature, gives high yields of various functional α-substituted cycloalkenes.The reaction can be applied to lithium enolates of esters and need no catalyst, but may be performed with HMPA as cosolvent.It is illustrated by a short (6 steps) and efficient total selective synthesis of (+/-)-mitsugashiwalactone from 2,5-dimethoxytetrahydrofuran with 33percent overall yield.