129543-90-4Relevant articles and documents
Synthesis and human leukocyte elastase inhibitory evaluation of phosphate triesters and acyl phosphates of penam sulfides and sulfones
Laborde, Maria,Pezzenati, German,Yovaldi, Patricia,Mascaretti, Oreste A.,Rossi, Rolando C.,Pablo Rossi, Juan
, p. 2113 - 2117 (2001)
The synthesis of 6,6-dibromo-3α-(diphenylphosphate)oxymethyl-2,2-dimethyl penam sulfone (3a), 6α-chloro-3α-(diphenylphosphate)oxymethyl-2,2-dimethyl penam sulfone (3b), benzyl 6α-(diphenyl-phosphate)oxypenicillanate sulfone (4) and 6,6-dibromo-3α-(methylphosphate)carbonyl-2,2-dimethylpenam sulfone (12) are reported. When tested as inhibitors of human leukocyte elastase, the compound 4 proved to be the most active.
REACTIVITY PARAMETERS OF THE METAL ASSISTED 1,2-CLEAVAGE OF PENICILLINS
Alpegiani, Marco,Bodeschi, Angelo,Bissolino, Pierluigi,Visentin, Giuseppina,Zarini, Franco,et al.
, p. 617 - 628 (2007/10/02)
A straightforward and smooth conversion of penicillins into 1,2-secopenicillanates is described.The thiazolidine ring opening is brought about by the co-operative effect of strong non-nucleophilic bases and thiophilic heavy metal salts.The nature of the l