129560-03-8

Basic information

• Product Name: 4-(4-methylphenoxy)-Benzenemethanamine
• Synonyms: 4-(4-methylphenoxy)-Benzenemethanamine;BenzeneMethanaMine, 4-(4-Methylphenoxy)-
• CAS NO: 129560-03-8
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.28
• Mol File: 129560-03-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-methylphenoxy)-Benzenemethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methylphenoxy)-Benzenemethanamine(129560-03-8)
• EPA Substance Registry System: 4-(4-methylphenoxy)-Benzenemethanamine(129560-03-8)

Safety Data

• Hazardous Substances Data: 129560-03-8(Hazardous Substances Data)

Usage

General Description

4-(4-methylphenoxy)-Benzenemethanamine is a chemical compound that belongs to the class of aromatic amines. It consists of a benzene ring with a methanamine group and a 4-(4-methylphenoxy) substituent. 4-(4-methylphenoxy)-Benzenemethanamine is commonly used in the synthesis of pharmaceuticals and is known for its potential biological activity. It has been studied for its potential as an antipsychotic and analgesic agent, as well as for its use in the treatment of neurodegenerative disorders. Additionally, the compound has been evaluated for its potential as an anti-cancer agent. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 37563-42-1 4-(4'-methylphenoxy)benzonitrile 
• 106-44-5 p-cresol 
• 1194-02-1 4-fluorobenzonitrile 
• 1192-96-7 potassium p-cresolate 
• 623-03-0 4-Cyanochlorobenzene 

Downstream Products

• 1185088-71-4 N-[4-(4-methylphenyloxy)phenyl]methyl-2-aminonicotinic acid amide 
• 1185089-98-8 N-[4-(4-methylphenyloxy)phenyl]methyl-2-amino-6-methylnicotinic acid amide 

Relevant articles and documents

Preparation method of substituted phenoxy benzylamine compound and preparation method of pyrazole carboxamide compound

The invention discloses a preparation method of a substituted phenoxy benzylamine compound. P-halobenzonitrile is taken as an initial raw material, R'OH is taken as a solvent in the presence of R'OM, the substituted phenoxy benzylamine compound is obtained through hydrogen reduction, and the preparation method has the advantages of high yield and high purity. The invention also discloses a preparation method of pyrazole carboxamide. The preparation method of pyrazole carboxamide comprises the following steps: salifying the substituted phenoxy benzylamine compound, and reacting with a substituted pyrazole acyl chloride compound to prepare the pyrazole carboxamide compound at an expected high yield. The preparation methods provided by the invention have the advantages of high product purity, high yield, low solvent loss and low production cost.

Design, synthesis, insecticidal, and acaricidal activities of novel pyrimidinamine derivatives containing a biphenyl ether

A series of original pyrimidinamine derivatives containing a biphenyl ether moiety were designed and synthesized. Their structures were confirmed by 1H NMR, MS, and elemental analyses. Their insecticidal activities against lepidopteran and hemiptera insects and acaricidal activities were tested. The results of bioassay demonstrated that 9k showed the best activity (LC50 = 2.08 mg/L) against Tetranychus urticae, which is comparable with the positive control, spirotetramat (LC50 = 2.27 mg/L), and 9g showed better activity (LC50 = 0.52 mg/L) against Aphis fabae than the positive control, imidacloprid (LC50 = 1.02 mg/L), and relatively good activity (LC50 = 2.49 mg/L) against T urticae. Their structure-activity relationships indicated that both an ethyl group on the 4-position of the pyrimidine ring and alkyl chain as a para-substituent group of the benzene ring showed good biological activity.