129594-41-8

Basic information

• Product Name: 4-Nitro-benzoic acid (R)-1-((2S,3S)-3-trimethylsilanyl-oxiranyl)-non-3-ynyl ester
• Synonyms: 4-Nitro-benzoic acid (R)-1-((2S,3S)-3-trimethylsilanyl-oxiranyl)-non-3-ynyl ester
• CAS NO: 129594-41-8
• Molecular Weight: 403.55
• Mol File: 129594-41-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Nitro-benzoic acid (R)-1-((2S,3S)-3-trimethylsilanyl-oxiranyl)-non-3-ynyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-benzoic acid (R)-1-((2S,3S)-3-trimethylsilanyl-oxiranyl)-non-3-ynyl ester(129594-41-8)
• EPA Substance Registry System: 4-Nitro-benzoic acid (R)-1-((2S,3S)-3-trimethylsilanyl-oxiranyl)-non-3-ynyl ester(129594-41-8)

Safety Data

• Hazardous Substances Data: 129594-41-8(Hazardous Substances Data)

Upstream product

• 119238-88-9 1-(trimethylsilyl)-1(E)-undecen-5-yn-3-ol 
• 129594-40-7 [(E)-3-(1-Ethoxy-ethoxy)-undec-1-en-5-ynyl]-trimethyl-silane 
• 120891-49-8 4-(1'-ethoxyethoxy)-6-(trimethylsilyl)-5(E)-hexen-1-yne 
• 119119-60-7 1-(trimethylsilyl)-1(E)-hexen-5-yn-3-ol 
• 58107-34-9 (E)-3-trimethylsilyl-2-propenal 
• 110-53-2 1-Bromopentane 
• 119119-61-8 2(S)-<1'(S)-hydroxy-3'-nonynyl>-3(S)-(trimethylsilyl)oxirane 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 114616-11-4 14,15-didehydroleukotriene B4 

Relevant articles and documents

Highly Stereocontrolled Total Synthesis of Leukotriene B4, 20-Hydroxyleukotriene B4, Leukotriene B3, and Their Analogues

A highly stereocontrolled and practical new method for synthesis of LTB4 (1), 20-OH-LTB4 (2), and LTB3 (3) has been developed, which uses the palladium catalyzed coupling reaction of the vinylborane 5, derived from the C(1)-C(9) fragment 4, with the corresponding C(10)-C(20) fragments 6a-c.The acetylene 4 was synthesized by palladium-copper-catalyzed coupling reaction of (trimethylsilyl)acetylene with the bromide 12, which was prepared from γ-(trimethylsilyl)allylic alcohol (S)-10 by bromination followed by debromosilylation.The alcohol (S)-10 was obtained by the kinetic resolution of the racemate dl-10 using the Sharpless reagent.The vinyl iodides 6a and 6b were prepared from racemic γ-(trimethylsilyl)allylic alcohols dl-17 and dl-28, respectively, by the Sharpless kinetic resolution followed by the reactions taking advantage of the reactivity of vinylsilane moiety, while the segment 6c was prepared by the Sharpless kinetic resolution of racemic γ-iodoallylic alcohol dl-34 followed by protection.By using this method, precursors of the radiolabeled LTB4, and 20-OH-LTB4, i.e., 14,15-didehydro-LTB4 (40) and 14,15-didehydro-20-OH-LTB4 (41), respectively, were also synthesized.Similarly the novel structural analogue of LTB 42-44 were prepared.