129599-90-2 Usage
Description
Acetic acid, fluoro(phenylsulfinyl)-, ethyl ester, also known as ethyl fluoro(phenylsulfinyl)acetate, is a colorless liquid with a fruity odor and belongs to the class of organofluorine compounds. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, characterized by its formula C10H11FO2S.
Uses
Used in Pharmaceutical Industry:
Acetic acid, fluoro(phenylsulfinyl)-, ethyl ester is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its organofluorine nature contributes to the development of new drugs with improved properties, such as enhanced bioavailability and therapeutic efficacy.
Used in Agrochemical Industry:
In the agrochemical industry, Acetic acid, fluoro(phenylsulfinyl)-, ethyl ester serves as a key intermediate in the production of agrochemicals. Its incorporation into these compounds can lead to the development of more effective and targeted pesticides and other agricultural chemicals.
Safety Precautions:
It is crucial to handle Acetic acid, fluoro(phenylsulfinyl)-, ethyl ester with care due to its potential to cause irritation to the skin, eyes, and respiratory system upon exposure. Proper protective equipment should be used during its handling and storage. Additionally, it should be stored in a cool, dry place away from direct sunlight and sources of heat to prevent degradation or hazardous reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 129599-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,5,9 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 129599-90:
(8*1)+(7*2)+(6*9)+(5*5)+(4*9)+(3*9)+(2*9)+(1*0)=182
182 % 10 = 2
So 129599-90-2 is a valid CAS Registry Number.
129599-90-2Relevant articles and documents
Reactive resin facilitated preparation of an enantiopure fluorobicycloketone
Wong, Audrey,Welch, Christopher J.,Kuethe, Jeffrey T.,Vazquez, Enrique,Shaimi, Mohamed,Henderson, Derek,Davies, Ian W.,Hughes, David L.
, p. 168 - 174 (2007/10/03)
A facile preparation of enantiopure ethyl (1S,SS,6S)-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate 1 is described. The key feature of the synthesis involves copper-catalyzed enantioselective intramolecular cyclopropanation of a diazoketone to form enado-fluorocyclopropane 1 in a single operation. Removal of a problematic chloroketone impurity using a reactive resin treatment enabled a high throughput enantiopurity upgrade by chiral HPLC. The development of a scalable synthesis of 1 is presented, including details of the selection of catalyst and ligand optimization, incorporation of a reactive resin treatment and selection of chiral HPLC media and conditions.
Ethyl phenylsulfinyl fluoroacetate, a new and versatile reagent for the preparation of α-fluoro-α,β-unsaturated carboxylic acid esters
Allmendinger, Thomas
, p. 4905 - 4914 (2007/10/02)
The title compound 2 can be alkylated with a wide range of alkyl halides and Michael acceptors. Subsequent thermal elimination of phenyl sulfinic acid 3 leads to α-fluoro-α,β-unsaturated ethyl carboxylates 5 and 10, an important class of intermediates for fluorine containing biologically active compounds.
