1296084-57-5Relevant articles and documents
Synthesis of oseltamivir conjugates with lactose analogs for inhibition studies on Trypanosoma cruzi trans-sialidase
Giorgi, M. Eugenia,Piuselli, Damian,Agusti, Rosalia,De Lederkremer, Rosa M.
experimental part, p. 260 - 271 (2011/06/23)
Trypanosoma cruzi, the agent of Chagas disease, expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host glycoconjugates to mucins of the parasite. Crystallographic studies showed two sites in the catalytic r