129622-62-4Relevant articles and documents
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Tran, Thuy-Anh,Kramer, Bryan,Shin, Young-Jun,Vallar, Pureza,Boatman, P. Douglas,Zou, Ning,Sage, Carleton R.,Gharbaoui, Tawfik,Krishnan, Ashwin,Pal, Biman,Shakya, Sagar R.,Garrido Montalban, Antonio,Adams, John W.,Ramirez, Juan,Behan, Dominic P.,Shifrina, Anna,Blackburn, Anthony,Leakakos, Tina,Shi, Yunqing,Morgan, Michael,Sadeque, Abu,Chen, Weichao,Unett, David J.,Gaidarov, Ibragim,Chen, Xiaohua,Chang, Steve,Shu, Hsin-Hui,Tung, Shiu-Feng,Semple, Graeme
, p. 913 - 927 (2017/02/19)
The design and synthesis of a new series of potent non-prostanoid IP receptor agonists that showed oral efficacy in the rat monocrotaline model of pulmonary arterial hypertension (PAH) are described. Detailed profiling of a number of analogues resulted in