129625-34-9

Basic information

• Product Name: N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea
• Synonyms: N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea
• CAS NO: 129625-34-9
• Molecular Formula: C10H8 F3 N3 O4 S
• Molecular Weight: 323.2484
• Mol File: 129625-34-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 171 °C(Solv: methanol (67-56-1); water (7732-18-5))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.58g/cm³
• PKA: 6.01±0.70(Predicted)
• CAS DataBase Reference: N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea(129625-34-9)
• EPA Substance Registry System: N-methoxycarbonyl N'-2-nitro-4-trifluoromethylphenyl thiourea(129625-34-9)

Safety Data

• Hazardous Substances Data: 129625-34-9(Hazardous Substances Data)

Upstream product

• 35266-49-0 methoxycarbonylisothiocyanate 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Relevant articles and documents

In vivo morphological damage induced by a new benzimidazole prodrug in Echinococcus multilocularis metacestodes

Benzimidazoles are the most widely used compounds in chemotherapy of alveolar hydatid disease (AHD), but long-term administration is required to reach detectable plasma levels. N-Methoxycarbonyl N'-2-nitro-4-trifluoromethyl phenyl thiourea (2) was prepared as a potential prodrug of (5-trifluoromethyl-1H-benzimidazole-2-yl)-carbamic acid methyl ester. Biological effects of 2 were evaluated in gerbils (Meriones unguiculatus) against the causative agent of AHD, Echinococcus multilocularis metacestodes, through a transmission electron microscopy study. Significant morphological damage of tegument and protoscolices occurred after an 18-day treatment. The treatment of AHD by using the prodrug form of the benzimidazole deserves further study.