129655-21-6 Usage
Description
Bizelesin is a member of the cyclopropylpyrroloindole family, which is known for causing genomic DNA lesions by alkylating DNA. It is distinct from Adozelesin, another member of the same family, as Bizelesin induces both single-strand DNA lesions and double-strand DNA cross-links, while Adozelesin induces only single-strand DNA lesions. Bizelesin also affects cell proliferation through different pathways, inducing senescence as opposed to apoptosis induced by Adozelesin.
Uses
Used in Pharmaceutical Industry:
Bizelesin is used as a pharmaceutical agent for its DNA-damaging properties. It is particularly effective in inducing both single-strand lesions and double-strand DNA cross-links, which can be useful in the development of cancer treatments.
Used in Cancer Research:
In cancer research, Bizelesin is used as a tool to study the effects of DNA damage on cell proliferation and the mechanisms behind cell senescence. Its ability to induce double-strand DNA cross-links makes it a valuable compound for understanding the cellular responses to various types of DNA damage.
Used in Drug Development:
Bizelesin's unique DNA-damaging capabilities can be harnessed in the development of new drugs targeting cancer cells. Its potential to induce senescence, rather than apoptosis, may offer alternative treatment strategies for certain types of cancer.
Used in Combination Therapies:
Bizelesin can be explored for its potential synergistic effects when combined with other chemotherapeutic drugs. This could enhance the overall efficacy of cancer treatments, particularly in cases where resistance to conventional chemotherapy has developed.
Check Digit Verification of cas no
The CAS Registry Mumber 129655-21-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,6,5 and 5 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 129655-21:
(8*1)+(7*2)+(6*9)+(5*6)+(4*5)+(3*5)+(2*2)+(1*1)=146
146 % 10 = 6
So 129655-21-6 is a valid CAS Registry Number.
InChI:InChI=1/C43H36Cl2N8O5/c1-19-15-46-39-33(54)11-31-37(35(19)39)23(13-44)17-52(31)41(56)29-9-21-7-25(3-5-27(21)50-29)48-43(58)49-26-4-6-28-22(8-26)10-30(51-28)42(57)53-18-24(14-45)38-32(53)12-34(55)40-36(38)20(2)16-47-40/h3-12,15-16,23-24,46-47,50-51,54-55H,13-14,17-18H2,1-2H3,(H2,48,49,58)/t23-,24?/m1/s1
