129716-87-6

Basic information

• Product Name: 4-(diphenylmethyl)-alpha-((quinolinyloxy)methyl)-1-piperazinoethanol
• Synonyms: 4-(diphenylmethyl)-alpha-((quinolinyloxy)methyl)-1-piperazinoethanol
• CAS NO: 129716-87-6
• Molecular Formula: C29H31 N3 O2
• Molecular Weight: 0
• Mol File: 129716-87-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 624.5°C at 760 mmHg
• Flash Point: 331.5°C
• Appearance: /
• Density: 1.198g/cm³
• Vapor Pressure: 1.84E-16mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: 4-(diphenylmethyl)-alpha-((quinolinyloxy)methyl)-1-piperazinoethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(diphenylmethyl)-alpha-((quinolinyloxy)methyl)-1-piperazinoethanol(129716-87-6)
• EPA Substance Registry System: 4-(diphenylmethyl)-alpha-((quinolinyloxy)methyl)-1-piperazinoethanol(129716-87-6)

Safety Data

• Hazardous Substances Data: 129716-87-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C29H31N3O2/c33-25(22-34-28-15-16-30-27-14-8-7-13-26(27)28)21-31-17-19-32(20-18-31)29(23-9-3-1-4-10-23)24-11-5-2-6-12-24/h1-16,25,29,33H,17-22H2

Upstream product

• 611-36-9 quinolin-4-ol 
• 111452-72-3 1-(diphenylmethyl)-4-(2,3-epoxypropyl)piperazine 
• 841-77-0 diphenylmethylpiperazine 
• 106-89-8 epichlorohydrin 

Relevant articles and documents

Synthesis and Biological Activity of 4-(Diphenylmethyl)-α--1-piperazineethanol and Related Compounds

A series of 4-(diphenylmethyl)-α--1-piperazineethanol and closely related compounds was synthesised and evaluated for cardiac and vascular activity in isolated perfused rat and guinea pig hearts.Compound 1 produced greater inotropic effects in rat hearts than in guinea pig hearts, a phenomenon which was also observed with the prototype agent DPI 201-106.Compound 15 produced an inotropic effect with one-tenth the potency of compound 1.Both compounds 1 and 15 demonstrated direct inotropic and vasodilatory effects when administered iv in anesthetized dogs, although the vasodilatory activity was more pronounced with compound 15 than 1 and DPI compound.Compound 1 lacks the CN moiety which is a key structural requirement in DPI for positive inotropic activity.The synthesis, in vitro, and in vivo evaluations of these agents, and comparative data with DPI-201-106 (compound 17) are reported.