129720-85-0

Basic information

• Product Name: (S)-1-tert-butyl 2-(cyclohexylcarbamoyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-1-tert-butyl 2-(cyclohexylcarbamoyl)pyrrolidine-1-carboxylate
• CAS NO: 129720-85-0
• Molecular Weight: 296.41
• Mol File: 129720-85-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (S)-1-tert-butyl 2-(cyclohexylcarbamoyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-tert-butyl 2-(cyclohexylcarbamoyl)pyrrolidine-1-carboxylate(129720-85-0)
• EPA Substance Registry System: (S)-1-tert-butyl 2-(cyclohexylcarbamoyl)pyrrolidine-1-carboxylate(129720-85-0)

Safety Data

• Hazardous Substances Data: 129720-85-0(Hazardous Substances Data)

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 108-91-8 cyclohexylamine 
• 141874-26-2 N-Boc-(S)-proline chloride 

Downstream Products

• 921936-85-8 1,1'-(propane-1,3-diyl)bis(N-cyclohexylpyrrolidine-2-carboxamide) 
• 95729-83-2 (S)-N-cyclohexyl-pyrrolidine-2-carboxamide 
• 129720-87-2 Z-Gly-Pro-Arg(Mts)-Pro-cyclohexylamine 
• 129720-86-1 Boc-Arg(Mts)-Pro-cyclohexylamine 
• 129720-88-3 H-Arg(Mts)-Pro-cyclohexylamine 

Relevant articles and documents

Simple and facile l-prolinamides derived from achiral cycloalkylamines as organocatalysts for the highly efficient large-scale asymmetric direct aldol reactions

A series of N-cycloalkylprolinamides have been designed and synthesized from achiral cycloalkylamines in a facile manner. They promoted high stereoselectivity in the cross-aldol reaction. N-cyclopropylprolinamide performed best with a smallest carbocyclic

The development of new amine-amide ligands for application in Cu(II)-catalyzed enantioselective Henry reactions

A new type of chiral tertiary amine ligand was designed and derived from l-proline and (R)-BINOL. These new chiral ligands chelated with Cu(II) showed highly catalytic efficiency in enantioselective Henry reactions. Excellent yields (up to 99%) and high enantioselectivities (up to 96% ee) were achieved for aromatic, hetero-aromatic and aliphatic aldehyde substrates, without an additional base additive or the need for air or moisture exclusion.

Asymmetric intramolecular aldol reaction mediated by (S)-N-substituted-N- (2-pyrrolidinylmethyl)amine to prepare Wieland-Miescher ketone

New or known N-substituted-N-(2-pyrrolidinylmethyl)amine derivatives bearing a variety of alkyl and aryl substituents were easily prepared from N-Boc-proline or N-Boc-N-(2-pyrrolidinylmethyl)amine. The enantioselectivity of the intramolecular asymmetric aldol reaction mediated by a combination of the amine derivative and TFA to prepare Wieland-Miescher ketone was examined. During the examination, optimal amount of TFA in the reaction was identified. The Japan Institute of Heterocyclic Chemistry.