129746-42-5

Basic information

• Product Name: 3-THIEN-3-YLBENZALDEHYDE
• Synonyms: AKOS BAR-0207;3-THIOPHEN-3-YL-BENZALDEHYDE;3-THIEN-3-YLBENZALDEHYDE;3-(3-THIENYL)BENZALDEHYDE;3-(3-THIENY)BENZALDEHYDE;3-(2-Acetylthiophen-3-yl)benzaldehyde;3-(2-Carboxythiophen-3-yl)benzaldehyde;3-(2-Formylthiophen-3-yl)benzaldehyde
• CAS NO: 129746-42-5
• Molecular Formula: C₁₁H₈OS
• Molecular Weight: 188.25
• EINECS: 604-604-1
• Mol File: 129746-42-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 302.865 °C at 760 mmHg
• Flash Point: 114.963 °C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-THIEN-3-YLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-THIEN-3-YLBENZALDEHYDE(129746-42-5)
• EPA Substance Registry System: 3-THIEN-3-YLBENZALDEHYDE(129746-42-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 129746-42-5(Hazardous Substances Data)

Usage

General Description

3-Thien-3-ylbenzaldehyde is a chemical compound with the molecular formula C12H8OS. It is an organic compound that contains both a thiophene ring and a benzaldehyde group. 3-THIEN-3-YLBENZALDEHYDE is commonly used in the synthesis of various pharmaceuticals and organic compounds, and it is also utilized as a building block in the production of other chemical compounds. 3-Thien-3-ylbenzaldehyde exhibits unique chemical properties due to the presence of the thiophene ring, making it valuable in organic synthesis and pharmaceutical research. It is known for its aromatic and pungent odor, and it is often used as a scent in perfumes and fragrances.

InChI:InChI=1/C11H8OS/c12-7-9-2-1-3-10(6-9)11-4-5-13-8-11/h1-8H

Upstream product

• 6165-69-1 Thien-3-ylboronic acid 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 298220-77-6 [3-(3-Thienyl)benzyl]-[2-([5-fluoro-2-isopropoxy]-phenoxy)ethyl]amine 
• 155294-75-0 3-(thien-3-yl)cinnamoyl chloride 
• 155294-02-3 (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[3-(3-thienyl)benzylamino)benzylamine 
• 155294-07-8 (E)-N-ethyl-N-(6-methoxy-6-methyl-2-hepten-4-ynyl)-3-[3-(3-thienyl)benzylamino]benzylamine 

Relevant articles and documents

Discovery of novel “Dual-site” binding oseltamivir derivatives as potent influenza virus neuraminidase inhibitors

From our research group, it was noticed that oseltamivir derivatives targeting 150-cavity of neuraminidase enzyme (NA) could significantly increase antiviral activity. Thus, we further enriched the C5–NH2 position of oseltamivir structure to ob

[2-substituted-5-[3-thienyl)-benzyl]-2- ([2-isopropoxy-5-fluoro]-phenyoxy)-ethyl]-amine derivatives, method for the production and use thereof as medicaments

The present invention relates to novel [(2-substituted-5-[3-thienyl])-benzyl]-[2-([2-isopropoxy-5-fluoro]-phenoxy)-ethyl]-amine derivatives having formula (1) and the use thereof as medicaments, especially anti-psychotic medicaments.

Substituted alkylamine derivatives

The substituted alkylamine derivatives represented by formula (I) STR1 wherein R1 represents (a) substituted or unsubstituted C2-6 alkenyl group, (b) substituted or unsubstituted C3-6 cycloalkenyl group, (c) substituted or unsubstituted C2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru11 -Ar wherein R11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; STR2 represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R7, X and Y are linking groups, R2 is H or lower alkyl, R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R4 and R5 are independently hydrogen or halogen atoms, R6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-methyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.