129757-52-4

Basic information

• Product Name: (R)-N-(methoxycarbonyl)-2-amino-4-phenylbutane
• Synonyms: (R)-N-(methoxycarbonyl)-2-amino-4-phenylbutane
• CAS NO: 129757-52-4
• Molecular Weight: 207.272
• Mol File: 129757-52-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-N-(methoxycarbonyl)-2-amino-4-phenylbutane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(methoxycarbonyl)-2-amino-4-phenylbutane(129757-52-4)
• EPA Substance Registry System: (R)-N-(methoxycarbonyl)-2-amino-4-phenylbutane(129757-52-4)

Safety Data

• Hazardous Substances Data: 129757-52-4(Hazardous Substances Data)

Upstream product

• 1118755-40-0 C₁₉H₂₃NO₃ 
• 127222-03-1 <2S,1R>-methyl <2-<(2-methoxyethoxy)methyl>-1-pyrrolidyl>(1-methyl-3-phenylpropyl)carbamate 

Downstream Products

• 937-52-0 (R)-1-methyl-3-phenylpropylamine 
• 129757-61-5 (R)-N-(3,5-dinitrobenzoyl)-α-methylbenzenepropanamine 
• 129757-61-5 (S)-N-(3,5-dinitrobenzoyl)-2-amino-4-phenylbutane 

Relevant articles and documents

Studies on the bisoxazoline- and (-)-sparteine-mediated enantioselective addition of organolithium reagents to imines

The enantioselective addition of organolithium reagents to N-anisylaldimines promoted by chiral bisoxazolines and (-)-sparteine as external ligands is described. This reaction proceeds readily with a wide range of aldimine substrates (aliphatic, aromatic, olefinic) and organolithium nucleophiles (Me, n-Bu, Ph, vinyl) in excellent yields (81-99%) and with high enantioselectivities (up to 97:3.0 er). The external ligands can be used in substoichiometric amounts albeit with slightly attenuated enantioselectivities. A systematic evaluation of the structural features of the bisoxazolines revealed a primary contribution from the substituent at C(4) and a secondary influence from the bridging substituents. A computational analysis (PM3) provided a clear rationalization for the origin of enantioselectivity.