1297600-31-7

Basic information

• Product Name: C₂HF₃O₂*C₂₂H₂₅N₃O₂S₂
• CAS NO: 1297600-31-7
• Molecular Weight: 541.615
• Mol File: 1297600-31-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂HF₃O₂*C₂₂H₂₅N₃O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂HF₃O₂*C₂₂H₂₅N₃O₂S₂(1297600-31-7)
• EPA Substance Registry System: C₂HF₃O₂*C₂₂H₂₅N₃O₂S₂(1297600-31-7)

Safety Data

• Hazardous Substances Data: 1297600-31-7(Hazardous Substances Data)

Upstream product

• 78364-18-8 1-oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid 
• 17339-60-5 bis[2-(N,N-dimethylamino)ethyl]disulfide dihydrochloride 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening

Disulfide exchange screening is a method for evaluating the binding of small molecule fragments to proteins that have at least one accessible cysteine. While operationally simple, it does require a large library of small fragment molecules bearing disulfide-containing side chains. These specialized fragments are not available commercially and this has limited the adoption of the method. We report here a convenient one-pot procedure that enables facile preparation of disulfide screening fragments while also producing less of an environmental impact. The new synthetic method involves the initial formation of symmetric disulfides, followed by a disulfide exchange reaction in which the symmetrical dimer is converted into the final screening fragment by introduction of a solubilizing ?cap?. The method is amenable to parallel synthetic methods and can be carried out in air without the need for the specialized equipment typically required for performing organic synthesis.