129790-97-2Relevant articles and documents
Condensed heterocyclic compounds
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, (2008/06/13)
The invention relates to compounds of the formula STR1 wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, independently, hydrogen, lower-alkyl, lower-alkoxy or halogen; R5 and R6 are, independently, hydrogen or lower-alkyl; R7 is hydroxy, lower-alkoxy or NR8 R9 ; R8 and R9 are, independently, hydrogen or lower-alkyl; X and Y are, independently, >CR14 R15, --O--, --S--, >SO, >SO2 or >NR18 ; R10 and R18 are, independently, hydrogen, lower-alkyl or acyl; M is --C(R11)=C(R12)--, --CONH-- or --NH--CO--; R11, R12, R14 and R15 are, independently, hydrogen or lower-alkyl, R13 is hydrogen, lower-alkoxycarbonyl or lower- alkyl, which can be substituted by amino, mono-alkylamino, di-alkylamino, morpholino, thiomorpholino or piperazino; and n is 1, 2, 3 or 4; with the proviso that at least one of X and Y comprises a hetero atom and n is 1, 3 or 4 when X contains a hetero atom, Y is >C(CH3)2 and R1 is lower-alkyl or --CH2 OR10 or --COR7, or a salt of a compound of formula I, when R1 is carboxy. The compounds of formula I are useful in the treatment of prophylaxis of neoplasms, dermatoses and ageing of the skin.
