1298016-99-5

Basic information

• Product Name: C₁₉H₁₅N₅O₄S
• CAS NO: 1298016-99-5
• Molecular Weight: 409.425
• Mol File: 1298016-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₅N₅O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₅N₅O₄S(1298016-99-5)
• EPA Substance Registry System: C₁₉H₁₅N₅O₄S(1298016-99-5)

Safety Data

• Hazardous Substances Data: 1298016-99-5(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 70386-38-8 D,L-1-bromo-3-phthalimido-2-butanone 
• 38985-70-5 4-(4-nitrophenyl)-3-thiosemicarbazide 
• 21860-84-4 2-phthalimidopropionic acid 

Relevant articles and documents

Synthesis and antiviral activity of novel 1,3,4-thiadiazine derivatives

A series of novel 1,3,4-thiadiazine derivatives were synthesized via chemical optimization on phthiobuzone. Their anti-herpes simplex virus (HSV) activities in vitro were also tested. Several compounds exhibited more highly potent anti-HSV activity and much higher selectivity index (SI) values than those of phthiobuzone. The most potent anti-HSV compound was 4f, which showed marked inhibition against HSV-1 (IC50=77.04μg/ml) and HSV-2 (IC50=30.00μg/ml). Meanwhile it had low cytotoxicity (CC 50=1000.00μg/ml), resulting in high (SIHSV-1= 12.98, SIHSV-2=33.33, respectively). Furthermore, a computational study for prediction of absorption, distribution, metabolism, excretion (ADME) properties of compound 4f was performed by determination of topological polar surface area, absorption and Lipinski parameters.