1298085-51-4

Basic information

• Product Name: 2,3-dihydrotrichostatin A
• CAS NO: 1298085-51-4
• Molecular Weight: 304.389
• Mol File: 1298085-51-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,3-dihydrotrichostatin A(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydrotrichostatin A(1298085-51-4)
• EPA Substance Registry System: 2,3-dihydrotrichostatin A(1298085-51-4)

Safety Data

• Hazardous Substances Data: 1298085-51-4(Hazardous Substances Data)

Upstream product

• 58880-19-6 trichostatin A 

Relevant articles and documents

Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell lung cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties. (Chemical Equation Presented).