129822-44-2

Basic information

• Product Name: (2-Benzyl-phenyl)-carbamic acid tert-butyl ester
• Synonyms: (2-Benzyl-phenyl)-carbamic acid tert-butyl ester
• CAS NO: 129822-44-2
• Molecular Weight: 283.37
• Mol File: 129822-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-Benzyl-phenyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Benzyl-phenyl)-carbamic acid tert-butyl ester(129822-44-2)
• EPA Substance Registry System: (2-Benzyl-phenyl)-carbamic acid tert-butyl ester(129822-44-2)

Safety Data

• Hazardous Substances Data: 129822-44-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 28059-64-5 2-benzylaniline 

Downstream Products

• 3456-79-9 3-phenyloxindole 
• 138343-96-1 2,3-diphenylindole-1-carboxylic acid tert-butyl ester 
• 129822-50-0 tert-butyl 3-phenyl-1H-indole-1-carboxylate 
• 3469-20-3 2,3-diphenyl-1H-indole 
• 138344-46-4 2-Hydroxy-3-phenyl-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 138343-95-0 [2-(2-Oxo-1,2-diphenyl-ethyl)-phenyl]-carbamic acid tert-butyl ester 
• 138344-47-5 (2-tert-Butoxycarbonylamino-phenyl)-phenyl-acetic acid 

Relevant articles and documents

Preparation of indoles and oxindoles from N-(tert-butoxycarbonyl)-2-alkylanilines

Treatment of dilithiated N-(tert-butoxycarbonyl)anilines 1 with dimethylformamide or carbon dioxide furnishes intermediates 3, 5, that are easily converted to N-(tert-butoxycarbonyl)indoles 4 and oxindoles (indol-2(3H)-ones, 7), respectively. Condensation of dilithiated 1 with N-methoxy-N-methylamides provides ketones 9 which are cyclized upon trifluoroacetic acid treatment to either 2-substituted 1-(tert-butoxycarbonyl)indoles 10 or 2-substituted indoles 11 depending on the reaction time. This general methodology has been applied to efficient synthesis of 1,2-alkyl-bridged indoles 12, 1,3,4,5-tetrahydrobenz[c,d]indole (16), 2a,3,4,5-tetrahydrobenz[c,d]indol-2(1H)-one (18), and 1-(tert-butoxycarbonyl)1H-pyrrolo[2,3-b]pyridine (21).