129848-87-9

Basic information

• Product Name: PROPIO-2,2-D2-PHENONE
• Synonyms: PROPIO-2,2-D2-PHENONE
• CAS NO: 129848-87-9
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 136.19
• Mol File: 129848-87-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PROPIO-2,2-D2-PHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPIO-2,2-D2-PHENONE(129848-87-9)
• EPA Substance Registry System: PROPIO-2,2-D2-PHENONE(129848-87-9)

Safety Data

• Hazardous Substances Data: 129848-87-9(Hazardous Substances Data)

Usage

Uses

Propio-2,2-d2-phenone (CAS# 129848-87-9) is a useful isotopically labeled research compound.

Upstream product

• 93-55-0 1-phenyl-propan-1-one 
• 2114-03-6 2,2-dibromo-1-phenylpropan-1-one 
• 673-32-5 1-Phenylprop-1-yne 
• 811-98-3 d⁽⁴⁾-methanol 

Downstream Products

• 134839-88-6 (2,2-dideuterio-propyl)-benzene 
• 40543-62-2 (2-deuterio-propenyl)-benzene 
• 343777-45-7 N,N-dimethyl hydrazone de la propiophenone (d2-2) 

Relevant articles and documents

Organocatalytic Deuteration Induced by the Dynamic Covalent Interaction of Imidazolium Cations with Ketones

In this article, we suggest a new organocatalytic approach based on the dynamic covalent interaction of imidazolium cations with ketones. A reaction of N-alkyl imidazolium salts with acetone-d6 in the presence of oxygenated bases generates a dynamic organocatalytic system with a mixture of protonated carbene/ketone adducts acting as H/D exchange catalysts. The developed methodology of the pH-dependent deuteration showed high selectivity of labeling and good chiral functional group tolerance. Here we report a unique methodology for efficient metal-free deuteration, which enables labeling of various types of α-acidic compounds without trace metal contamination. (Figure presented.).

Br?nsted Acid Catalyzed Friedel–Crafts-Type Coupling and Dedinitrogenation Reactions of Vinyldiazo Compounds

The direct Friedel–Crafts-type coupling and dedinitrogenation reactions of vinyldiazo compounds with aromatic compounds using a metal-free strategy are described. This Br?nsted acid catalyzed method is efficient for the formation of α-diazo β-carbocations (vinyldiazonium ions), vinyl carbocations, and allylic or homoallylic carbocation species via vinyldiazo compounds. By choosing suitable nucleophilic reagents to selectively capture these intermediates, both trisubstituted α,β-unsaturated esters, β-indole-substituted diazo esters, and dienes are obtained with good to high yields and selectivity. Experimental insights implicate a reaction mechanism involving the selective protonation of vinyldiazo compounds and the subsequent release of dinitrogen to form vinyl cations that undergo intramolecular 1,3- and 1,4- hydride transfer processes as well as fragmentation.

Iron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Br?nsted Acid Catalysis

Alkylarylalkynes are converted with full regioselectivity into the corresponding arylketones by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (≤95 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes into acetyl derivatives via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by π-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system. (Figure presented.).