129872-82-8 Usage
General Description
2,4-dichloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine, also known as EC-145, is a chemical compound with potential pharmaceutical applications. It belongs to the pyrrolopyrimidine family and is a potent inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme plays a key role in the de novo synthesis of pyrimidine nucleotides, which are essential for DNA and RNA synthesis. Inhibiting DHODH can disrupt the growth of cancer cells and the replication of certain viruses, making EC-145 a potential candidate for the development of anticancer and antiviral drugs. Additionally, it has shown promise in preclinical studies for the treatment of autoimmune and inflammatory diseases. Further research and clinical trials are needed to fully understand its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 129872-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,8,7 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 129872-82:
(8*1)+(7*2)+(6*9)+(5*8)+(4*7)+(3*2)+(2*8)+(1*2)=168
168 % 10 = 8
So 129872-82-8 is a valid CAS Registry Number.
129872-82-8Relevant articles and documents
Pyrrolo pyrimidine derivate and application thereof
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Paragraph 0037-0039; 0057-0059, (2017/11/18)
The invention belongs to the field of medicinal chemistry, and specifically relates to a pyrrolo pyrimidine derivate. The structure of the pyrrolo pyrimidine derivate is shown as formula (I), wherein X and Y independently represent N, O and S or SO; R1 is
