129996-40-3Relevant articles and documents
Synthesis, characterization and in vivo anthelmintic activity of some novel N-Mannich bases of benzimidazoles
Murti, Yogesh,Arora, Rashmi,Pathak, Devender
, p. 627 - 631 (2011/08/05)
As a part of ongoing efforts towards finding novel anthelmintic agents, N-Mannich bases of benzimidazole were obtained by condensation of substituted secondary amines and aldehyde in ethanol. These compounds were identified on the basis of melting point range, Rf values, elemental analysis, IR and 1H NMR spectral analysis. The synthetic work is fruitless without performing biological activities, so the newly synthesized compounds were screened for pharmacological activity. Anthelmintic activity was carried out against Eudrilus species of earthworms.
Facile synthesis of N-dialkylaminomethyl-substituted heterocycles
Love, Brian E.
, p. 630 - 632 (2007/10/03)
Iminium ions are generated by treatment of aminals with succinic anhydride. These iminium ions are trapped by heterocycles, giving the corresponding N-dialkylamino-methyl-substituted heterocycles, which are easily separated from the succinic acid monoamid