130049-78-4 Usage
Description
2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) is a chemical compound belonging to the benzopyran family. It is a chiral molecule with the (2S) configuration and is characterized by the presence of a carbonyl chloride group at the 2-position and a 3,4-dihydro ring structure. 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) serves as an important intermediate in the synthesis of various pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) is used as a key intermediate in the synthesis of (S)-9-Hydroxy Risperidone-d4 (H953362). 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) is the S-enantiomer metabolite of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. Risperidone is widely used in the treatment of various psychiatric disorders, such as schizophrenia, bipolar disorder, and irritability associated with autistic disorder. The synthesis of (S)-9-Hydroxy Risperidone-d4 through the use of 2H-1-Benzopyran-2-carbonylchloride,3,4-dihydro-,(2S)-(9CI) allows for the development of more effective and targeted therapies for these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 130049-78-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,0,4 and 9 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 130049-78:
(8*1)+(7*3)+(6*0)+(5*0)+(4*4)+(3*9)+(2*7)+(1*8)=94
94 % 10 = 4
So 130049-78-4 is a valid CAS Registry Number.
130049-78-4Relevant articles and documents
SUBSTITUTED CHROMAN COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS
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Paragraph 0395, (2015/02/19)
The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.