130049-85-3 Usage
Description
(R)-9-Hydroxy Risperidone, also known as R525000, is the R-enantiomer metabolite of Risperidone, a pharmaceutical compound that acts as a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist. It is an important metabolite in the pharmacological profile of Risperidone and plays a significant role in the drug's therapeutic effects.
Uses
Used in Pharmaceutical Industry:
(R)-9-Hydroxy Risperidone is used as an active pharmaceutical ingredient for the treatment of various psychiatric disorders, such as schizophrenia, bipolar disorder, and irritability associated with autistic disorder. Its action as a combined serotonin and dopamine receptor antagonist helps in managing the symptoms of these conditions by modulating the neurotransmitter levels in the brain.
Additionally, (R)-9-Hydroxy Risperidone can be used as a research tool in the development of new drugs targeting the serotonin and dopamine receptors, as well as in studying the mechanisms of action and pharmacokinetics of Risperidone and its metabolites.
Check Digit Verification of cas no
The CAS Registry Mumber 130049-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,0,4 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 130049-85:
(8*1)+(7*3)+(6*0)+(5*0)+(4*4)+(3*9)+(2*8)+(1*5)=93
93 % 10 = 3
So 130049-85-3 is a valid CAS Registry Number.
130049-85-3Relevant articles and documents
Preparation method for paliperidone palmitate
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, (2017/08/23)
The invention discloses a preparation method for paliperidone palmitate. The preparation method comprises the following steps: step 1, synthesis of 3-(2-hydroxyethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyltetrahydro-pyridino[1,2-alpha]pyrimidin-4-one; step 2, synthesis of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyltetrahydro-pyridino[1,2-alpha]pyrimidin-4-one; step 3, synthesis of paliperidone; and step 4, synthesis of paliperidone palmitate. Compared with the prior art, the preparation method provided by the invention has the advantages of short reaction time, low cost, controllability of impurities, easiness in purification, high product purity and high yield.
NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE
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, (2011/12/13)
The present invention relates to a novel process for the preparation of paliperidone and its intermediates and also relates to an improved process for the preparation of paliperidone compound of formula (I).
PREPARATION OF PALIPERIDONE
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, (2009/03/07)
Processes for preparing paliperidone.