130064-26-5

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[4-[( tetrahydro-2H-pyran-2-yl)oxy]phenyl]-
• CAS NO: 130064-26-5
• Molecular Formula: C31H32O7
• Molecular Weight: 516.591
• Mol File: 130064-26-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[4-[( tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[4-[( tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(130064-26-5)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-7-[(tetrahydro-2H-pyran-2-yl)oxy]-3-[4-[( tetrahydro-2H-pyran-2-yl)oxy]phenyl]-(130064-26-5)

Safety Data

• Hazardous Substances Data: 130064-26-5(Hazardous Substances Data)

Upstream product

• 17720-60-4 2,4,4'-trihydroxy deoxybenzoin 
• 156-38-7 4-hydroxyphenylacetate 
• 108-46-3 recorcinol 
• 130064-21-0 1-(2-hydroxy-4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)ethanone 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1443752-89-3 C₃₃H₃₅NO₈ 
• 1443773-82-7 C₃₉H₄₉NO₇ 
• 1443752-76-8 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol 
• 1443752-77-9 (2R)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol 
• 1443752-79-1 (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-chromen-7-ol hydrochloride 
• 1443752-90-6 C₂₉H₃₁NO₅ 
• 1443752-93-9 C₃₅H₃₉NO₈ 
• 1443752-92-8 C₃₉H₄₇NO₆ 
• 1443752-91-7 C₂₉H₃₃NO₁₀P₂ 
• 1443752-88-2 C₂₉H₃₃NO₁₀P₂ 
• 1443773-55-4 2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)chroman-4-one 

Relevant articles and documents

NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF

Benzopyran compounds with strong anti-estrogenic activity and essentially no estrogenic activity are provided, which are OP- 1038, which is 3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-l-yl]ethoxy}phenyl)-2H-chromen-7-ol, and OP-1074, which is (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin- 1 -yl]ethoxy}phenyl)-2H-chromen-7-ol. OP-1074 is a pure anti-estrogen when tested in the agonist mode and a complete anti-estrogen when tested in the antagonist mode. These compounds are useful for the treatment or prevention of a variety of conditions that are modulated through the estrogen receptor in mammals including humans.

Benzopyran-containing compounds and prodrug forms thereof

Certain benzopyran antiestrogens are disclosed for treating estrogen sensitive diseases such as breast cancer. Prodrug forms provide ease of manufacturing, good shelf life, and bioavailibility.

Structure-Activity Relationship of Antiestrogens. Phenolic Analogues of 2,3-Diaryl-2H-1-benzopyrans

Phenolic analogues of 2--3-phenyl-2H-1-benzopyran (1), a novel antiestrogen, were synthesized and evaluated for their structure-activity relationship.Incorporation of OH at position 7 was found to improve receptor affinity of