1300746-10-4Relevant articles and documents
BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION
-
Paragraph 00821; 00822, (2015/06/11)
Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
BENZOTRIAZOLODIAZEPINE COMPOUNDS INHIBITORS OF BROMODOMAINS
-
Page/Page column 34-35, (2012/01/13)
Benzodiazepine compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
